BACKGROUND A well-known complication of peripheral nerve block is peripheral nerve injury, whether from the needle or toxicity of the medication used. In this study, we sought to determine the extent of damage that results from intrafascicular injection of various commonly used local anesthetics (LAs). METHODS Sixteen Lewis rats received an intrafascicular injection of saline (control) or 1 o...

visualization was an issue in both reports. Using an out-of-plane approach may have prevented proper needle visualization because only a cross section of the needle anywhere in the length of the needle may be seen and mistaken for the tip, although tissue movement may have been seen. With the in-plane approach used in the other report, needle artifacts may have prevented proper visualization, w...

Systemic administration of local anesthetics has beneficial perioperative properties and an anesthetic-sparing and antiarrhythmic effect, although the detailed mechanisms of these actions remain unclear. In the present study, we investigated the effects of a local anesthetic, lidocaine, on hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels that contribute to the pacemaker cu...

The overdiagnosis of thyroid malignancies may be contributing to the increased incidence of these cancers with a relatively stable mortality rate. We present the case of a man with known malignancies, who underwent biopsy of a suspicious thyroid nodule. This procedure was complicated by local anesthetic systemic toxicity (LAST). It is important to address goals of diagnostic testing and treatme...

OBJECTIVE Paresthesia is an adverse event that may be associated with the administration of local anesthetics in dentistry. The purpose of this retrospective study was to analyze cases of paresthesia associated with local anesthetic injection that were voluntarily reported to Ontario"s Professional Liability Program (PLP) from 1999 to 2008 inclusive, to see if the findings were consistent with ...

OBJECTIVES THE AIM OF THIS STUDY WAS TO ANALYZE CLINICAL RECORDS OF DENTAL PATIENTS ATTENDING THE DENTAL DEPARTMENT AT THE UNIVERSITY OF JORDAN HOSPITAL: a teaching hospital in Jordan. Analysis aimed at determining whether dental specialists properly documented the drug prescriptions and local anesthetic injections given to their patients. METHODS Dental records of the Dental Department at th...

STUDY DESIGN Comparative assessment of randomized controlled trials of caudal and lumbar interlaminar epidural injections in chronic lumbar discogenic pain. OBJECTIVE To assess the comparative efficacy of caudal and lumbar interlaminar approaches of epidural injections in managing axial or discogenic low back pain. SUMMARY OF BACKGROUND DATA Epidural injections are commonly performed utiliz...