نتایج جستجو برای: local anesthetic action
تعداد نتایج: 1119077 فیلتر نتایج به سال:
The current recommendations regarding maximum doses of local anesthetics presented in textbooks, or by the responsible pharmaceutical companies, are not evidence based (ie, determined by randomized and controlled studies). Rather, decisions on recommending certain maximum local anesthetic doses have been made in part by extrapolations from animal experiments, clinical experiences from the use o...
PURPOSE Intravenous lipid emulsions have been used to treat the systemic toxicity of local anesthetics. The goal of this in vitro study was to examine the effects of lipid emulsions on the norepinephrine-mediated reversal of vasodilation induced by high doses of levobupivacaine, ropivacaine, and mepivacaine in isolated endothelium-denuded rat aorta, and to determine whether such effects are ass...
Many different receptors, ion channels, are involved in the pathophysiology of pain, which can serve as targets for adjuvant drugs. Despite advent long-acting local anesthetics, improvement their pharmacokinetics, and advanced regional anesthesia techniques, they do not fully meet need treatment especially chronic pain. In parallel with increase anesthetic power risk systemic toxicity increases...
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