Our study was aimed to characterize the phenotype and functional endpoints of local microwave hyperthermia (LHT, 42 degrees C) on tumor infiltrating and spleen leukocytes. The effectiveness of LHT applied into the tumor of B16F10 melanoma-bearing C57/BL6 mice was compared with anesthetized and non-treated animals. Subpopulations of leukocytes were analyzed using the flow cytometry, and the cyto...

Vol. 30, No. 1, 2018 107 Received November 1, 2016, Revised December 29, 2016, Accepted for publication January 26, 2017 Corresponding author: Yan Wu, Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China. Tel: 86-24-83282116, Fax: 86-24-83282633, E-mail: [email protected] Xinghua Gao, Department of Dermatology, No. 1 Hospital of C...

BACKGROUND Local hyperthermia of tumor in conjunction with chemotherapy is a promising strategy for cancer treatment. The aim of this study was to evaluate the efficacy of intratumoral delivery of clinically approved magnetic nanoparticles (MNPs) conjugated with doxorubicin to simultaneously induce magnetic hyperthermia and drug delivery in a hepatocellular carcinoma (HCC) model. MATERIALS AN...

PURPOSE Hyperthermia has been used in several trials to treat pelvic cancers without excessive toxicity and with positive results. The aim of this study was to evaluate feasibility and results in terms of biochemical recurrence-free, disease-free survival, overall survival, and treatment toxicity profile of hyperthermia combined with radiotherapy in locally advanced high risk prostate cancer. ...

Radiotherapy and chemotherapy are the standard interventions for cancer patients, although cells often develop radio- and/or chemoresistance. Hyperthermia reduces tumor resistance induces immune responses resulting in a better prognosis. We have previously described method to induce cell death by local hyperthermia employing pegylated reduced graphene oxide nanosheets near infrared light (graph...

OBJECTIVES Malignant hyperthermia susceptibility is an important risk factor during general anesthesia. Affected patients have an asymptomatic but potentially lethal hypermetabolic reaction after contact with volatile anesthetics or succinylcholine. Classic symptoms include hemodynamic instability, combined with acidosis, rigor, and hyperthermia. During cardiopulmonary bypass, these signs may b...

The role of active oxygen species and lipid peroxidation in the antitumor effect of hyperthermia was studied in an experimental rabbit model. VX2 tumors were transplanted into rabbit hind legs, and the effect of hyperthermia on tumor growth was measured at 7 and 14 days after heating. As an index of lipid peroxidation, thiobarbituric acid-reactive substances in the tumor tissue were measured pr...

how to cite this article: saeedi borujeni mj, hami j, haghir h, rastin m, sazegargh. evaluation of bax and bcl-2 proteins expression in the rat hippocampus due to childhood febrile seizure. iran j child neurol. winter 2016; 10(1):53-60. abstract objective simple febrile seizure (sfs) is the most common seizure disorder in childhood, and is frequently described as inoffensive disorder. neverthel...

The effect of sequence and timing of hyperthermia (43 degrees) and bleomycin on Chinese hamster cells (V79) has been investigated. Hyperthermia preceding bleomycin treatment produced a greater cytotoxic effect than bleomycin treatment preceding hyperthermia. Furthermore, it appears that the combination of hyperthermia and bleomycin becomes less effective if the application of bleomycin is delay...