We evaluated the capacity of adeno-associated virus (AAV) vectors to transduce primitive human myeloid progenitor cells derived from marrow and cord blood in long-term cultures and long-term culture-initiating cell (LTC-IC) assays. Single-colony analyses showed that AAV vectors transduced CD34(+) and CD34(+)38(-) clonogenic cells in long-term culture. Gene transfer was readily observed in LTC-I...

Abstract Background Older adults in long-term care (LTC) homes experience high rates of fractures, which are detrimental to their quality life. The purpose this study is identify and make recommendations on strategies implementing an evidence-based Fracture Risk Clinical Assessment Protocol (CAP) LTC. Methods Following the Behaviour Change Wheel framework, we conducted six focus group interview...

PURPOSE To explore residents' and family members' perceptions of partnership-centered long-term care (LTC) associated with implementation of the Tri-focal Model of Care. The Model promotes partnership-centered care, evidence-based practice, and a positive environment. Its implementation is supported by a specifically designed education program. METHODS The Model was implemented over approxima...

OBJECTIVES The aim of this study was to identify the effects of community-based home healthcare projects that influence service performances with regard to Korean national long-term care insurance services in older adults. METHODS The project's applicants were 18 operational agencies in national long-term care institutions in Korea, and participants were care recipients (n = 2263) registered ...

This paper describes and examines a change program for nursing services in Complex: Continuing/Long Term Care (CC/LTC) at the Baycrest Centre for Geriatric Care in Toronto. It presents a brief history of the rise of CC/LTC services and the difficulties associated with them. In particular it claims that demographic, professional and insti tutional changes have produced a differentiated specializ...

The aim of this paper is to assess the role of culture in shaping individual preferences towards different long-term care (LTC) arrangements. The analysis uses Swiss data from two administrative databases covering the universe of formal LTC providers between 2007 and 2013. Switzerland is a multi-cultural confederation where state administrative borders do not always coincide with cultural group...

OBJECTIVES The aim of this study was to create a French equivalent of the revised Algase wandering scale for long-term care (RAWS-LTC). METHODS The RAWS-LTC French version (F-RAWS-LTC), Mini-Mental State Examination, and Neuropsychiatric Inventory were administered to a sample of 100 institutionalized patients from 12 specialized homes. RESULTS The mean of the overall F-RAWS-LTC was 2.32 (s...

BACKGROUND The majority of frail elderly who live in long-term care (LTC) are not treated for osteoporosis despite their high risk for fragility fractures. Clinical Practice Guidelines for the diagnosis and management of osteoporosis provide guidance for the management of individuals 50 years and older at risk for fractures, however, they cannot benefit LTC residents if physicians perceive barr...

This study used Monte Carlo simulations to examine the ability of the two-stage least squares (2SLS) estimator and two-stage residual inclusion (2SRI) estimators with varying forms of residuals to estimate the local average and population average treatment effect parameters in models with binary outcome, endogenous binary treatment, and single binary instrument. The rarity of the outcome and th...

OBJECTIVES Long term care (LTC) residents commonly experience transitions between health care settings that can have important health consequences. The objective of this study was to quantify the effect of recent transitions on the risk of emergency department (ED) transfer among chronic LTC residents. Two types of transitions were considered: admission into LTC and discharge from hospital. D...