نتایج جستجو برای: low copy nuclear gene
تعداد نتایج: 2427466 فیلتر نتایج به سال:
We assessed DNA methylation and copy number status of 27,000 CpGs in 149 urothelial carcinomas and integrated the findings with gene expression and mutation data. Methylation was associated with gene expression for 1,332 CpGs, of which 26% showed positive correlation with expression, i.e., high methylation and high gene expression levels. These positively correlated CpGs were part of specific t...
Sickle cell disease (SCD) is a widespread genetic associated with severe disability and multi-organ damage, resulting in reduced life expectancy. None of the existing clinical treatments provide solution for all patients. Gene therapy fetal haemoglobin (HbF) reactivation through approaches have obtained promising, but early, results Furthermore, search active molecules to increase HbF still ong...
Background: Nuclear receptor binding SET domain protein-3 (NSD3) is a histone lysine methyltransferase and crucial regulator of carcinogenesis in several cancers. We aimed to investigate the prognostic value potential function NSD3 33 types human cancer. Methods: The data were obtained from Cancer Genome Atlas. Kaplan-Meier analysis, CIBERSORT, gene set enrichment variation analys...
In vitro culture (IVC), used in assisted reproductive technologies, is a major environmental stress on the embryo. To evaluate the effect of IVC on mitochondrial transcription and the control of mtDNA replication, we measured the mtDNA copy number and relative amount of mRNA for mitochondrial-related genes in individual rat oocytes, zygotes and embryos using real-time PCR. The average mtDNA cop...
In higher eukaryotes, tRNA multigene families comprise several copies encoding the same tRNA isoacceptor species. Of the 11 copies of a tRNA1Gly family from the mulberry silkworm Bombyx mori, individual members are differentially transcribed in vivo in the B. mori-derived BmN cell lines and in vitro in silk gland nuclear extracts. These genes have identical coding regions and hence harbour iden...
Many studies have suggested that the 3D organization of chromatin and proteins within the nucleus contributes to the regulation of gene expression. We tested multiple aspects of this nuclear organization model within a primary cell culture system. Oligodendrocyte lineage cells were examined to facilitate analysis of nuclear organization relative to a highly expressed tissue-specific gene, prote...
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