This series presents research findings based either directly on data from the German SocioEconomic Panel Study (SOEP) or using SOEP data as part of an internationally comparable data set (e.g. CNEF, ECHP, LIS, LWS, CHER/PACO). SOEP is a truly multidisciplinary household panel study covering a wide range of social and The decision to publish a submission in SOEPpapers is made by a board of edito...

Implementations of the Wald-Marré technique have employed fixed luminance backgrounds to isolate cone sensitivity mechanisms. We evaluated the effect of varying the adaptation level on the relative isolation of the different cone types. For MWS and LWS cone isolation we used a 15 Hz flickering test light to isolate the achromatic channel, and we modelled the resulting spectral sensitivity funct...

A long-term selection experiment for high or low 8-wk BW in White Plymouth Rock chickens was conducted to study effects of selection on BW and correlated characters. Two lines [high (HWS), low (LWS) weight] were established and have undergone 48 generations of selection. The lines were managed to curtail inbreeding and to maintain similar population structures; such is necessary for equitable c...

Much is known regarding the evolution of colour vision in nearly every vertebrate class, with the notable exception of the elasmobranchs. While multiple spectrally distinct cone types are found in some rays, sharks appear to possess only a single class of cone and, therefore, may be colour blind. In this study, the visual opsin genes of two wobbegong species, Orectolobus maculatus and Orectolob...

The effects of nanoparticle (NP) properties, such as size, shape and surface charge, on their efficacy and toxicity have been studied extensively. However, the effect of controlled drug release on NP efficacy and toxicity has not been thoroughly evaluated in vivo. Our study aims to fill this knowledge gap. A key challenge in characterizing the relationship between drug release and therapeutic r...

with the p.R110X mutation, as was described recently (13). Although p.R110X is one of the few recurrent mutations of this gene, we were unable to find other clinical descriptions of female patients carrying this mutation , and the movement disorder in CLS, although common, is not well studied. No clear hot spot mutations were found, thus highlighting the functional relevance of both protein kin...

editorial 60 years of POMC a j l clark and p lowry 56:4 E1–E2 Proopiomelanocortin (POMC) has been at the forefront of molecular endocrinology for the past 60 years, and the concepts derived from POMC research have led the way in understanding a wide range of endocrine systems. In this issue, we celebrate this enormous body of work with contributions from an outstanding faculty of contributors, ...

is published in full as a supplement to this number of the Journal. At the conclusion of the Oration, Dr. John Rankin proposed a vote of thanks to Dr. Campbell. He said previous orators had all known Robert Campbell, but this was the first time one who had not enjoyed his friendship had made his contribution. Robert Campbell was a scholar, and it was that happy blend of the scholarly and the sc...

The transcriptional activity of the integrated HIV provirus is dependent on the chromatin organization of the viral promoter and the transactivator Tat. Tat recruits the cellular pTEFb complex and interacts with several chromatin-modifying enzymes, including the histone acetyltransferases p300 and PCAF. Here, we examined the interaction of Tat with activation-dependent histone kinases, includin...

OBJECTIVES To assess the impact of the different types of contact lenses (CLs) on quality of life (QoL) in patients with keratoconus based on self-reported results from The Contact Lens Impact on Quality of Life (CLIQ) Questionnaire. METHODS Consecutive keratoconus patients who wore CLs (rigid gas permeable [RGP], hybrid or soft toric) at least in one eye were asked to complete the CLIQ quest...