Paeoniflorin (PF) is one of the main bioactive components of total glucosides of paeony (TGP) extracted from the root of Paeonia lactiflora Pall. TGP exhibit various biological activities such as improvement in memory, hepatoprotection, antimutagenic properties and platelet aggregation inhibition. The aim of this paper is to review the pharmacokinetics (PK) of PF as a pure compound and in singl...

概要 上室 性刺激 に伴 う心室 内変行伝導 の結果生 じる脚 ブ ロックは,一 般には生理的 なものであ り機 能的脚 ブロ ック(FBBB)1)~3)と いわれ る、 今回 このFBBBの 極形 である完全脚 ブロック(BBB)出 現 につ き50例 の正當PQ,正 QRS波 形例 を対 象 とし,心 房早期刺激法 と ヒス束心電図a)を使用 し検 討 し た.BBB出 現は50例 中31例(62%)に み られた.内 訳は右脚 ブロック(RBBB)21例,異 常 左軸 偏位 を伴 つた右 脚 ブロッ ク(RBBB+LAH)3例,異 常右軸 偏位 を伴つた右脚 ブロック(RBBB+LPH) 2例,左 脚 プロ ヅク(LBBB)3例, RBBB, LBBBの 両型 出現が2例 にみられ た, BBB出 現 の基 本条 件 としては よ り長 い心周期 の存 在,上 室性期外収縮(P...

The United States military has undergone numerous changes since the end of the Cold War. Specifically, the U.S. Navy experienced a shift in the area of engagement from the “blue water” water depth greater than 100 m to littoral regions of the world. The sea mines become the big threat in the naval operations. Within the past 15 years three U.S. ships, the USS Samuel B. Roberts FFG-58 , Tripoli ...

Immunization of mice with a combination of passively administered syngeneic IgG (anti-p-azophenylarsonate [anti-Ars]) antibody and a soluble, multivalent form of the antibody's corresponding antigen (Limulus polyphemus hemocyanin conjugated with Ars [Lph-Ars]) resulted in specific autoanti-IgG Fc (rheumatoid factor) production. The response was rapid and only anti-IgG of the IgM isotype is foun...

This paper reports an immunofluorescent study of the pituitary in the fetal pig (Sus scrofa). Fifteen antisera were used against most of the hormones present in the pituitary. Five types of hypophysial endocrine cells were observed in the anterior and intermediate lobes. We determined the sequential appearance of these various cell types in the fetus. The first hormones found at 33 days were AC...

Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked by a disulfide bond. The HC selectively binds to neurons and aids cell entry of the enzymatically active LC. There are seven immunological BoNT serotypes (...

editorial 60 years of POMC a j l clark and p lowry 56:4 E1–E2 Proopiomelanocortin (POMC) has been at the forefront of molecular endocrinology for the past 60 years, and the concepts derived from POMC research have led the way in understanding a wide range of endocrine systems. In this issue, we celebrate this enormous body of work with contributions from an outstanding faculty of contributors, ...

• Experimental demonstration of two stage desalination and cooling • Use of chilled water for condensation of humid air • Simulation of experimental results • Comparative study on conventional condensation and improved condensation • Improved design of proposed integrated plant a b s t r a c t a r t i c l e i n f o Humidification–dehumidification (HDH) desalination is a simple and cost effectiv...

This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. In addition, some unpublished data are presented Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene. Identification of a variant associated with adult-type hypolactasia. Transcriptional regul...