BACKGROUND The hemodynamics characteristics of the hybrid Norwood (HN) procedure differ from those of the conventional Norwood and are not fully understood. We present a multiscale model of HN circulation to understand local hemodynamics and effects of aortic arch stenosis and a reverse Blalock-Taussig shunt (RBTS) on coronary and carotid perfusion. METHODS Four 3-dimensional models of four H...

This study tested four sensitivity analysis methods: (1) local analysis using parameter estimation software (PEST), (2) regional sensitivity analysis (RSA), (3) analysis of variance (ANOVA), and (4) Sobol’s method to identify sensitivity tools that will advance our understanding of lumped hydrologic models for the purposes of model improvement, 5 calibration efficiency and improved measurement ...

A new Single-sided Variable Flux Permanent Magnet Linear Machine with flux bridge in mover core is proposed this paper. The prevents the leakage from and converts it into linkage, which greatly influences performance of machine. First, a lumped parameter model used to find suitable coil combination no-load linkage machine, reduces computational time drive storage. Secondly, machine replaces exp...

A method for transient analysis of single phase transmission lines based on state-space technique is presented. Transmission lines are considered as the interconnection of many lumped parameter sections. By this approach state equations are formulated for the system by choosing the capacitor voltages and inductor currents as the state variables. These equations are solved by state space techniq...

Coarctation of the aorta (COA) is an obstruction of the aorta and is usually associated with bicuspid and tricuspid aortic valve stenosis (AS). When COA coexists with AS, the left ventricle (LV) is facing a double hemodynamic load: a valvular load plus a vascular load. The objective of this study was to develop a lumped parameter model, solely based on non-invasive data, allowing the descriptio...

Leftward fluid flow in the mouse node is generated by cilia and is critical for initiating asymmetry of the left-right axis. Coiled-coil domain containing-40 (Ccdc40) plays an evolutionarily conserved role in the assembly of motile cilia and establishment of the left-right axis. Approximately one-third of Ccdc40lnks mutant embryos display situs defects and here we investigate the underlying mec...

The Windkessel model enlarges his applicativity on the whole circulatory dynamics studies. Then, the lumped parameter models allow global representation of blood flow circulation. In the vascular tree, peripheral branches are terminated by a resistance term representing smaller vessels. Blood flow and pressure are expressed by the intensity of current and voltage in an electrical analogue based...

In pediatric ventricular assist device (VAD) design, the process of matching device characteristics and dimensions to the relevant disease conditions poses a formidable challenge because the disease spectrum is more highly varied than for adult applications. One example arises with single-ventricle congenital defects, which demand palliative surgeries that create elevated systemic venous pressu...