The role of sex hormones in the pathogenesis of lung cancer is still unknown. There are conflicting results regarding immunohistochemical detection of the estrogen and progesterone receptors expression in non small cell lung cancer. To clarify these discrepancies 32 samples of lung carcinoma tissues obtained by lobectomy or pneumonectomy were studied. Two monoclonal antibodies (6F11 and ID5) fo...

Lung cancer is the leading cause of cancer-related mortality in the USA and worldwide, and of the estimated 1.2 million new cases of lung cancer diagnosed every year, over 30% are lung adenocarcinomas. The backbone of 1st-line systemic therapy in the metastatic setting, in the absence of an actionable oncogenic driver, is platinum-based chemotherapy. ATM and ATR are DNA damage signaling kinases...

Background and Objective: Epidermal growth factor receptor (EGFR) gene mutation, especially in exons 18 to 21, is an important predictor of the response rate of lung adenocarcinoma to tyrosine kinase inhibitors. There are variable reports from Asian and European countries, as well as North America, about the frequency of the EGFR mutation in lung adenocarcinoma, yet molecular s...

-------------------------------------------------------------------ABSTRACT-------------------------------------------------------------Cancers is defined as the uncontrolled cell divisions. Cell does not grow maturely and destined to uncontrolled cell growth. When these cells of lungs grow uncontrolled it is called lung cancer. Nowadays mortality rate due to lung cancer is increasing day by da...

T he Cell and Molecular Biology Assembly, in association with the Thoracic Oncology Assembly, has been leading a Task Force on an adenocarcinoma multidisciplinary classification, which includes histomolecular and radiological correlation as well as oncology and surgical management. With .1.3 million deaths annually [1, 2], lung cancer is the leading cause of cancer death worldwide [3, 4]. The d...

To the Editor: Lung cancer is the most common cause of cancer-related mortality worldwide for men and women, causing approximately 1.2 million deaths per year. 1 The absolute and relative frequencies of lung cancer have risen dramatically 1 and in South Africa account for 17% of all cancer deaths. 2 We found that adenocarcinoma is now the most common histological subtype of primary lung cancer ...

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) as a standard therapy have been used in EGFR-mutated adenocarcinoma of non-small-cell lung cancer (NSCLC) patients in recent years. But in current randomized prospective clinical trials, due to few cases of non-adenocarcinoma patients having been found, the efficacy of TKIs for EGFR-mutated non-adenocarcinoma and the rela...

Objective: To describe and improve our understanding of lung cancer epidemiology. Methodology: Retrospective, descriptive analytic epidemiological study, analyzing histological type, sex, age radiological results for in the municipality Sinop – MT during period from 2014 to 2019. Results: 219 lesion biopsies were analyzed. 113 (51.59%) confirmed a diagnosis cancer. The main types histopathology...

OBJECTIVES To estimate the relations between exposure to both tobacco smoke and crocidolite and the incidence of various histological types of lung cancer. METHODS In 1979 all former workers from the Wittenoom asbestos industry who could be traced were sent a questionnaire on smoking history. Of 2928 questionnaires sent, satisfactory replies were received from 2400 men and 149 women. Of the m...

ATP-binding cassette transporter E1 (ABCE1), also known as RLI (RNase L inhibitor), is a new type of endoribonuclease inhibitor, which can specifically bind to RNase L and abolish its effect. ABCE1 binds to eIF2α and eIF5 to form a pre-translation initiation complex, suggesting its crucial role in cell growth, development and certain pathological ...