A child showing signs of Henoch-Schönlein purpura developed a right tibiofibular vascular thrombosis. Antiphospholipid antibody tests were positive for both lupus anticoagulant and anticardiolipin antibodies. This suggests that an antiphospholipid syndrome should be considered in cases of Henoch-Schönlein purpura and antiphospholipid antibodies should be measured to determine whether prophylact...

Antiphospholipid syndrome (APS) is an acquired prothrombotic state characterized by recurrent thromboses, pregnancy loss, thrombocytopenia, and the presence of antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant and/or anti2-glycoprotein antibody. The original clinical and laboratory criteria for APS, called the Sapporo criteria, were first published in 1999. These were...

showed portal vein thrombosis with progression to superior and inferior mesenteric vein and splenic vein (Figure 1). Antithrombin III, protein C and S were normal; lupus anticoagulant 1.19 (<1.2); anticardiolipin antibody was positive (IgG 30.5/IgM 50: <10). Our patient meets the criteria for SLE and for APS [1,4]. APS is characterized by lupus anticoagulant, anticardiolipin antibodies, vascula...

OBJECTIVE To study the association of a variety of dermatological manifestations related to vascular abnormalities with antiphospholipid antibodies in patients with suspected primary antiphospholipid syndrome. METHOD Case-control study. Consecutive patients referred to the coagulation and haemostasis service of a general hospital for the first determination of antiphospholipid antibodies (lup...

Thrombotic lesions are consistently observed in chronic thromboembolic pulmonary hypertension (CTEPH) and frequently found in primary pulmonary hypertension (PPH). It remains unknown, however, whether thrombosis is related to defects of the antithrombotic pathway or to previous vascular injury. This study therefore analysed the frequency of both hereditary and acquired thrombotic risk factors i...

Antiphospholipid antibodies (APLA) are immunoglobulins of the lgG and lgM groups with activity against negatively charged phospholipids. Common manifestations of APLA include the presence of lupus anticoagulant and anticardiolipin antibodies, and false-positive Venereal Disease Research Laboratory (VORL) and rapid plasma reagin (RPR) tests [1 , 2]. APLA has been associated with an increased fre...

References 1. Mitsias P, Levine SR. Large cerebral vessel occlusive disease in systemic lupus erythematosus. Neurology. In press. 2. Dungan DD, Jay MS. Stroke in an early adolescent with systemic lupus erythematosus and coexistent antiphospholipid antibodies. Pediatrics. 1992;90:96-99. 3. Tsokos GC, Tsokos M, le Riche NGH, Klippel JH. A clinical and pathological study of cerebrovascular disease...