BACKGROUND Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer. METHODS In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohist...

Lymphatic malformation (LM) is a localized and rare benign anomaly of the lymphatic system. Surgery is the primary form of treatment, but total resection is difficult and generally not possible. The least invasive and most effective form of treatment is injection sclerotherapy with sclerosing agents. Here, we report a case of LM in a baby, detected at prenatal ultrasound. The aim of this report...

Vascular endothelial growth factor-A (VEGF-A) expression is up-regulated in several inflammatory diseases including psoriasis, delayed-type hypersensitivity (DTH) reactions, and rheumatoid arthritis. To directly characterize the biologic function of VEGF-A in inflammation, we evaluated experimental DTH reactions induced in the ear skin of transgenic mice that overexpress VEGF-A specifically in ...

Lung allografts are prone to rejection, even though recipients undergo aggressive immunosuppressive therapy. Lymphatic vessels serve as conduits for immune cell trafficking and have been implicated in the mediation of allograft rejection. In this issue of the JCI, Cui et al. provide compelling evidence that lymphatic vessel formation improves lung allograft survival in a murine transplant model...

The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged. This overview highlights recent advances in our understanding of the molecular mechanisms underly...

Sclerotherapy and surgery are both effective treatment methods for lymphatic malformations.1,2 However, recurrence due to incomplete resection is a common problem, often necessitating multiple treatment sessions.2 Intralesional endoscopy has been described as a diagnostic approach and potential therapeutic tool.1,3 We report a case of a 12-year-old male patient who presented with a mainly subcu...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, debilitating respiratory disease whose pathogenesis is poorly understood. In IPF, the lung parenchyma undergoes extensive remodeling. We hypothesized that lymphangiogenesis is part of lung remodeling and sought to characterize pathways leading to lymphangiogenesis in IPF. We found that the diameter of lymphatic vessels in alveolar s...

Lymphadenopathy or often known as lymphatic disease is a that very risky if not handled properly. There are so many signs symptoms of this have been to the public, some even consider it an ordinary lump grows on human body and do know they experiencing lymphadenopathy in themselves [3]. Usually find out lump, examination hospital consult doctor. Based these problems, technique method needed can...

purpose: to present a case of traumatic bilateral eyelid lymphedema. case report: an 18-year old male presented with severe bilateral eye lid lymphedema with a history of severe craniofacial trauma three month ago and neurosurgical procedure. he had lost vision in his left eye because of sever globe injury. his lymphedema was attributed to wide surgical incision scar. the patient underwent manu...

introduction: the lymphatic system provides one of the main paths for the spread (metastasis) of cancer from one part of body to another. hodgkin’s diseases, lymphocytic leukemia, various metastatic disease and many lymph node disorders can be assessed by lymphoscintigraphy. radionuclide lymphoscintigraphy has been used for many years to define lymphatic drainage of melanoma. the most common ra...