نتایج جستجو برای: lymphopenia

تعداد نتایج: 2617  

Journal: :The Journal of clinical investigation 2007
Claudio Anasetti James J Mulé

The combination of the induction of lymphopenia and vaccination and/or T cell transfer is garnering much attention for cancer treatment. Preclinical studies have shown that the induction of lymphopenia by chemotherapy or radiation can enhance the antitumor efficacy of several distinct, cell-based immunotherapeutic approaches. The mechanism(s) by which such enhancement is achieved are being inte...

2005
Tami Zaft Anita Sapoznikov Rita Krauthgamer Dan R. Littman Steffen Jung

The peripheral lymphocyte pool size is governed by homeostatic mechanisms. Thus, grafted T cells expand and replenish T cell compartments in lymphopenic hosts. Lymphopenia-driven proliferation of naive CD8 T cells depends on self-peptide/MHC class I complexes and the cytokine IL-7. Lymphopenia-driven proliferation and maintenance of memory CD8 T cells are MHC independent, but are believed to re...

2005
Tawee Chotpitayasunondh Kumnuan Ungchusak Wanna Hanshaoworakul Supamit Chunsuthiwat Pathom Sawanpanyalert Rungruen Kijphati Sorasak Lochindarat Panida Srisan Pongsan Suwan Yutthasak Osotthanakorn Tanakorn Anantasetagoon Supornchai Kanjanawasri Sureeporn Tanupattarachai Jiranun Weerakul Ruangsri Chaiwirattana Monthira Maneerattanaporn Rapol Poolsavatkitikool Kulkunya Chokephaibulkit Anucha Apisarnthanarak Scott F. Dowell

Influenza A (H5N1) is endemic in poultry across much of Southeast Asia, but limited information exists on the distinctive features of the few human cases. In Thailand, we instituted nationwide surveillance and tested respiratory specimens by polymerase chain reaction and viral isolation. From January 1 to March 31, 2004, we reviewed 610 reports and identified 12 confirmed and 21 suspected cases...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Joanne L Jones Sara A J Thompson Priscilla Loh Jessica L Davies Orla C Tuohy Allison J Curry Laura Azzopardi Grant Hill-Cawthorne Michael T Fahey Alastair Compston Alasdair J Coles

The association between lymphopenia and autoimmunity is recognized, but the underlying mechanisms are poorly understood and have not been studied systematically in humans. People with multiple sclerosis treated with the lymphocyte-depleting monoclonal antibody alemtuzumab offer a unique opportunity to study this phenomenon; one in three people develops clinical autoimmunity, and one in three pe...

Journal: :Journal of immunology 2005
Tami Zaft Anita Sapoznikov Rita Krauthgamer Dan R Littman Steffen Jung

The peripheral lymphocyte pool size is governed by homeostatic mechanisms. Thus, grafted T cells expand and replenish T cell compartments in lymphopenic hosts. Lymphopenia-driven proliferation of naive CD8+ T cells depends on self-peptide/MHC class I complexes and the cytokine IL-7. Lymphopenia-driven proliferation and maintenance of memory CD8+ T cells are MHC independent, but are believed to ...

Journal: :Blood 2006
Barbara Zemann Bernd Kinzel Matthias Müller Roland Reuschel Diana Mechtcheriakova Nicole Urtz Frédéric Bornancin Thomas Baumruker Andreas Billich

FTY720, a potent immunomodulatory drug in phase 2/3 clinical trials, induces rapid and reversible sequestration of lymphocytes into secondary lymphoid organs, thereby preventing their migration to sites of inflammation. As prerequisite for its function, phosphorylation of FTY720 to yield a potent agonist of the sphingosine-1-phosphate receptor S1P(1) is required in vivo, catalyzed by an as-yet-...

Journal: :Thalassemia Reports 2022

Transfusion-dependent thalassemia patients undergo transfusion immunomodulating effects, which result in a general immune response depression and, consequently, an increase the frequency of infectious episodes and neoplastic events due to reduction phagocytic function. Altered natural killer functions IL-2-mediated lymphocytic response, defects antigen presentation monocyte–macrophage cells, de...

Journal: :archives of pediatric infectious diseases 0
sedigheh rafiei tabatabaei pediatric infections research center, mofid children’s hospital, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) ali amanati professor alborzi clinical microbiology research center, shiraz university of medical sciences, shiraz, ir iran; professor alborzi clinical microbiology research center, shiraz university of medical sciences, shiraz, iran, amir oncology hospital; address: fars - shiraz - farhang shahr - against kosar pool, fax: +98-7136325655, postal code: +98-7187915998سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) abdollah karimi pediatric infections research center, mofid children’s hospital, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) kourosh goudarzipour pediatric congenital hemathologic disorders research center, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) zahra chavoshzadeh pediatric infections research center, mofid children’s hospital, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) maryam kazemi aghdam pediatric pathology research center, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

conclusions subcutaneous nodules in the absence of a local reaction at the site of bcg vaccination may be the sole manifestation of disseminated bcg disease. case presentation we report on an 11-months-old boy with prolonged fever and diffuse hyperpigmented subcutaneous nodules. due to lymphopenia, oral thrush and severe adverse reaction to bcg vaccination, the possibility of primary immunodefi...

Journal: :International journal of research publications 2022

Systemic Lupus Erythematosus (SLE) is an autoimmune illness with a broad range of clinical manifestations, one which hematological manifestations that cause high morbidity and mortality if there delay in diagnosis. This research was conducted to analyze the pattern SLE patients. descriptive retrospective study. A total 106 patients systemic lupus erythematosus met inclusion criteria. Patients w...

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