Lymphoproliferative disorders including non-Hodgkin lymphomas (NHL) are not uncommon neoplasms in patients infected with the human immunodeficiency virus (HIV). It has been established that HIV-infected individuals are more prone to develop certain lymphoproliferative disorders and lymphomas compared to non-infected individuals. The exact mechanisms underlying these associations is yet to be es...

PURPOSE OF REVIEW The autoimmune lymphoproliferative syndrome is a recently identified human disorder of lymphocyte apoptosis that has provided important information about Fas-mediated lymphocyte apoptosis. In this review we summarize current information regarding the diagnosis, management and underlying molecular basis of the syndrome. RECENT FINDINGS The genetic basis of autoimmune lymphopr...

2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function as a regulator of the 2B4-associated signal transduction pathway. In this study, we analyzed pat...

We report a patient with X-linked lymphoproliferative disease (XLP) who developed multiple central nervous system (CNS) manifestations of Epstein-Barr virus infection. XLP, or Duncan syndrome, is a rare inherited disorder characterized by the inability to clear Epstein-Barr virus infection. In addition to Epstein-Barr virus encephalitis, CNS lymphoproliferative disease, and lymphoma, this patie...

Citation: Saito S, Suzuki K, Yoshimoto K, Kaneko Y, Yamaoka K, Shimizu T, Mori T, Okamoto S, Kameyama K, Amano K, Tamaru J-i, Tokuhira M and Takeuchi T (2018) Restoration of Decreased T Helper 1 and CD8+ T Cell Subsets Is Associated With Regression of Lymphoproliferative Disorders Developed During Methotrexate Treatment. Front. Immunol. 9:621. doi: 10.3389/fimmu.2018.00621 restoration of Decrea...

Lymphoproliferative disorders following liver transplantation are often Epstein-Barr virus (EBV)-related highgrade B cell lymphomas. EBV-negative and low-grade lymphoma is a very rare condition after cadaveric as well as living donor liver transplantation (LDLT). Herein we report a case of follicular lymphoma with negative EBV viral capsid antigen (VCA), IgM, IgG and Epstein-Barr virus-encoded ...

Members of the Herpesviridae family have large doublestranded DNA genomes and replicate in the nucleus of the host cell. Based on genomic organization and biological characteristics, herpesviruses are classified into three subfamilies: alpha, beta, and gamma (Fig. 1A). The gammaherpesviruses replicate and persist in lymphoid cells, but some are capable of undergoing lytic replication in epithel...

CBCL: cutaneous B-cell lymphoma INTRODUCTION Cutaneous B-cell lymphomas (CBCL) are a heterogeneous group of lymphoproliferative diseases that can be classified in 2 broad categories: primary and secondary. The latter implies a systemic lymphoproliferative disease that causes visible cutaneous lesions. Numerous articles regarding the diagnosis and treatment of primary CBCL have been published. H...

Chronic HCV infection can predispose to different lymphoproliferative disorders including lymphomas (diffuse large B-cell lymphoma, marginal zone lymphoma, lymphoplasmacytic lymphoma) and plasma cell disorders (monocolonalgammopathies) [1,2]. Kelaidi et al reported a case of large granular lymphocyte leukemia occurring in association with Marginal Zone Lymphoma and HCV and responding to interfe...

The activity of natural killer cells was found to be deficient in 10 of 12 males with X-linked lymphoproliferative syndrome, a life-threatening proliferation of lymphocytes after infection by Epstein-Barr virus. The activity levels of natural killer cells from affected males were increased after treatment with interferon in vitro, but normal levels of killing were not obtained. Deficient activi...