نتایج جستجو برای: lyso
تعداد نتایج: 832 فیلتر نتایج به سال:
ero-3-phosphocholine) is a phospholipid that is synthesized by a variety of different cells and tissues in response to different stimuli, and is involved in numerous biological responses. Consequently, PAF is recognized as a major mediator that plays a central role in a variety of host defense system mechanisms and inflammatory diseases. Two pathways for PAF synthesis have been identified. One ...
Abstract Background and Aims Fabry disease (FD) is a multisystem lysosomal storage disorder caused by mutations in the GLA gene. The significance of mutation p.D313Y gene under debate. Our aim to evaluated pathogenic role D313Y. Method For clinical FD phenotype 60-year-old woman (index case) with cadaveric donor renal transplantation unknown cause was undergoing genetic investigation. She repor...
Almost all drug compounds will elicit deleterious effects on cells at some concentration. Lysosome perturbation as a result of ion trapping of amine containing compounds has been demonstrated to cause the formation of autophagosomes and autophagic cytopathology. Here we describe the use of the EL406TM Combination Washer Dispenser to automatically aspirate media, wash cells and dispense reagents...
Our goal is to develop a system with 100 picosecond time resolution for time of flight positron emission tomography [PET-TOF] using silicon photomultipliers (SiPMs). We have obtained a coincidence time resolution of 188 ps FWHM with two LYSO crystals (3x3x15 mm) coupled to SiPMs and irradiated with Na source. The best time resolution was obtained with the signal trimmed by a clipping capacitanc...
A total synthesis of the naturally occurring hydroxy ketone PEIPC 1, a compound that plays a role in endothelial activation in atherosclerosis, has been completed via a triply convergent preparation of a protected EI derivative 13 from 3,5-diacetoxycyclopentene 7, pentane-1,5-diol, and vinyllithium, using Sharpless epoxidation and enzymatic resolution as key steps. Final coupling with lyso-PC 1...
Abstract Background and Aims Fabry disease (FD) is not uncommon in patients with chronic kidney (CKD) who are on dialysis or have stroke at a young age, left ventricular hypertrophy (LVH) hypertrophic obstructive cardiomyopathy (HOCM). However, FD easily overlooked by physicians due to the heterogeneity of clinical manifestations. Therefore, an expert consensus meeting was held establish screen...
combined pet/ct scanners now play a major role in medicine for in vivo imaging in oncology, cardiology, neurology, and psychiatry. as the performance of a scanner depends not only on the scintillating material but also on the scanner design, with regards to the advent of newer scanners, there is a need to optimize acquisition protocols as well as to compare scanner performances on an objective ...
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