OBJECTIVE To study the effects of the somatostatin analog octreotide on gastric mucosal function and histology during short-term (3 months) preoperative treatment in patients with acromegaly. DESIGN Open design clinical study. METHODS 10 patients were studied before treatment with octreotide (pre-tx), on day 1 of 300 microg octreotide/day (d300), after 1 week on 300 (w300), 600 (w600) or 15...

BACKGROUND Most β-glucosidases reported are sensitive to the end product (glucose), making it the rate limiting component of cellulase for efficient degradation of cellulose through enzymatic route. Thus, there are ongoing interests in searching for glucose-tolerant β-glucosidases, which are still active at high glucose concentration. Although many β-glucosidases with different glucose-toleranc...

Measurements were made of respirable suspended particles (RSP) in a large sports tavern on 26 dates over approximately two years in which smoking was allowed, followed by measurements on 50 dates during the year after smoking was prohibited. The smoking prohibition occurred without warning when the city government passed a regulation restricting smoking in local restaurants and taverns. Two fol...

Anoplophora glabripennis (Motschulsky), has recently (since 1996) established in limited infestations near several cities in the United States. A. glabripennis was probably introduced into the United States with solid wood packing or dunnage. During 2001, we evaluated the current APHIS Schedule T404-b-1-1 for methyl bromide (MeBr) fumigation. Fumigations were conducted in 432-liter Lexan chambe...

To better understand and predict silage density in bunker silos, chopped whole-plant corn was placed in layers of 0.15, 0.30, 0.45, and 0.60 m in a 482584-mm rectangular container simulating the footprint of a tractor tire. Pressure between 20 and 80 kPa was applied to the forage by a platen. The total time of compaction varied between 1 and 10 s. A total of 25 tests were conducted with crop dr...

We will simplify the earlier proofs of Perelman’s collapsing theorem of 3-manifolds given by Shioya-Yamaguchi [SY00]-[SY05] and Morgan-Tian [MT08]. A version of Perelman’s collapsing theorem states that: “Let {M3 i } be a sequence of compact Riemannian 3-manifolds with curvature bounded from below by (−1) and diam(M3 i ) ≥ c0 > 0. Suppose that all unit metric balls in M3 i have very small volum...

G protein-coupled receptors (GPCRs) are known to initiate a plethora of signaling pathways in vitro. However, it is unclear which of these pathways are engaged to mediate physiological responses. Here, we examine the distinct roles of Gq/11-dependent signaling and receptor phosphorylation-dependent signaling in bronchial airway contraction and lung function regulated through the M3-muscarinic a...

The hyaluronan (HA) receptor for endocytosis (HARE) is a multifunctional recycling clearance receptor for 14 different ligands, including HA and heparin (Hep), which bind to discrete nonoverlapping sites. Four different functional endocytic motifs (M) in the cytoplasmic domain (CD) target coated pit mediated uptake: (YSYFRI(2485) (M1), FQHF(2495) (M2), NPLY(2519) (M3), and DPF(2534) (M4)). We p...

N-Methyl-D-aspartate (NMDA) receptors play a critical role in both development of the central nervous system and adult neuroplasticity. However, although the NMDA receptor presents a valuable therapeutic target, the relationship between its structure and functional properties has yet to be fully elucidated. To further explore the mechanism of receptor activation, we characterized two gain-of-fu...