The siderophore-based extraction of iron from the soil by bacteria is proposed as a model for a new separation methodology labeled the soil poultice, a molecular device that would selectively retrieve the complex of a targeted metal ion. In this first feasibility study we describe the synthesis and characterization of molecularly imprinted polymers based on noncovalent interactions, and their a...

BACKGROUND Useful probes of the intracellular environment that target a specific organelle in order to allow direct observation of the changes in these regions is of high current interest. Macrocyclic ligands have already revealed themselves as important selective hosts in some biological applications, forming stable and specific complexes. Therefore, in this paper, several macrocyclic ligands ...

Macrocyclic peptidomimetics are associated with a broad range of biological activities. However, despite such potentially valuable properties, the macrocyclic peptidomimetic structural class is generally considered as being poorly explored within drug discovery. This has been attributed to the lack of general methods for producing collections of macrocyclic peptidomimetics with high levels of s...

Dicopper(II) complexes of two new 3,5-disubstituted-pyrazole-based ligands, bis(quadridentate) macrocyclic ligand (L1)(2-) and bis(terdentate) acyclic ligand (L2)(-), were synthesised by Schiff base condensation of 3,5-diformylpyrazole and either one equivalent of 1,3-diaminopropane or two equivalents of 2-(2-aminoethyl)pyridine in the presence of one or two equivalents of copper(II) ions, resp...

Macrocyclic peptidomimetics are associated with a broad range of biological activities. However, despite such potentially valuable properties, the macrocyclic peptidomimetic structural class is generally considered as being poorly explored within drug discovery. This has been attributed to the lack of general methods for producing collections of macrocyclic peptidomimetics with high levels of s...

OBJECTIVES The purposes of this study were to evaluate the risk for analytical interference with gadolinium-based contrast agents (GBCAs) for the colorimetric measurement of serum iron (Fe³⁺) and to investigate the mechanisms involved. MATERIALS AND METHODS Rat serum was spiked with several concentrations of all molecular categories of GBCAs, ligands, or "free" soluble gadolinium (Gd³⁺). Seru...

Progress in the selective binding and detection of magnesium ions has been slower than other biologically important divalent metal like calcium zinc. The most widely used ligands for Mg2+ are by no means optimal, as they not it. Nevertheless, is a major cation all cells, with physiologically critical functions. There need improved sensors Mg2+. In this review, we consider how an appreciation fu...