نتایج جستجو برای: macromolecular antioxidants
تعداد نتایج: 35199 فیلتر نتایج به سال:
By PAT ROCHE, JR., M.D., RICHARD A. DODELIN, M.D. AND WALTER L. BLOOM, M.D. D EXTRAX is omie of the newest of macromolecular substances sihich have heems showns capal)le of expaiudimsg plasma volumme.15 Imi the past-, omse disadvanut-age to the imitravensous imujectionu of substances of large molecular size has heens the clumping amid! rounleaux formations of erythrocytes6’ which makes subseqin...
Molecules of mitochondrial cardiolipin (CL) get selectively oxidized upon oxidative stress, which triggers the intrinsic apoptotic pathway. In a chemical model most closely resembling the mitochondrial membrane-liposomes of pure bovine heart CL-we compared ubiquinol-10, ubiquinol-6, and alpha-tocopherol, the most widespread naturally occurring antioxidants, with man-made, quinol-based amphiphil...
Cryo-electron microscopy reconstruction methods are uniquely able to reveal structures of many important macromolecules and macromolecular complexes. EMDataBank.org, a joint effort of the Protein Data Bank in Europe (PDBe), the Research Collaboratory for Structural Bioinformatics (RCSB) and the National Center for Macromolecular Imaging (NCMI), is a global 'one-stop shop' resource for depositio...
Glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase are the major antioxidants at the cellular level and protect cell compartments against hydrogen peroxide (H2O2). In addition, they affect cellular processes such as cell signaling by modulating H2O2. In this paper we demonstrate that there is a synergetic coupling between GPxs, Prxs themselves and also with other antioxidants when ...
Proton nuclear magnetic resonance (NMR) imaging previously has been used to examine structure and pathologies of the eye. The present study investigates the use of a saturation-transfer technique, which exploits water-macromolecular proton magnetic interactions, to enhance image contrast in the rabbit eye in vivo. Upon steady-state saturation of the macromolecular-proton magnetization, the wate...
The future of macromolecular crystallography includes new X-ray sources, enhanced remote-accessible capabilities and time-resolved methods to capture intermediate structures along reaction pathways.
The conformation of a linear polymer chain is studied as a function of the concentration of a macromolecular crowding agent by neutron scattering. Excluded volume to random coil due to macromolecular crowding in cells is predicted to exert a compressive force that will tend to reduce its size. It is shown that when reducing free volume due to macromolecular crowding, we observe a compression of...
It has previously been shown that the presence of distinct regions of solvent and protein in macromolecular crystals leads to a high value of the standard deviation of local r.m.s. electron density and that this can in turn be used as a reliable measure of the quality of macromolecular electron-density maps [Terwilliger & Berendzen (1999a). Acta Cryst. D55, 501-505]. Here, it is demonstrated th...
The size and complexity of 3D macromolecular structures available in the Protein Data Bank is constantly growing. Current tools and file formats have reached limits of scalability. New compression approaches are required to support the visualization of large molecular complexes and enable new and scalable means for data analysis. We evaluated a series of compression techniques for coordinates o...
The combination of ordered macromolecular structures and well-defined responsive molecular triggers is enabling precise and amplified structural and property switching in synthetic architectures leading to useful functions. These features are reminiscent of the most sought after designs in nature, specifically the ability of superstructures to form on-demand, store information, perform actuatio...
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