[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

Peristaltic pumps are mechanical displacement pumps that induce flow in a fluid-filled, flexiblewalled conduit through peristalsis – transport due to traveling contraction waves. While macroscale peristaltic pumps appear in a variety of configurations, micropumps based on this principle almost exclusively use the sequenced contraction and expansion of a small number of discrete actuators – typi...

Mass transport phenomenon in concrete structures is strongly coupled with their mechanical behavior. The first coupling fabric the Biot's theory according to which fluid pressure interacts solid stress state and volumetric deformation rate of induces changes pressure. Another mechanism emerges cracks serve as channels for flow through them provide volume storage. Especially second presents a ch...

We present a fabrication technique that increases the resistance of PDMS to deformation under pressure driven flow and chemical solvents swelling without the use of any foreign materials. This is achieved by enhancing the material properties of PDMS by coupling two previously isolated processes. First, the weight ratio of the prepolymer to the curing agent was increased from 10:1 to 5:1, with t...

Results of 2D molecular dynamics (MD) method are presented for the mixing phenomenon in the microscale, where the length and time are measured in terms of microns and nanoseconds, respectively. Particle ensembles consisting of 0.7–3 × 106 particles in 1.3–5×105 timesteps were simulated. We focus on the temporal evolution of mixing layer between two superimposed Lennard–Jones particle systems in...

Long-term potentiation (LTP) is a form of activity-dependent plasticity that occurs during learning. Potassium channels are the most diverse group of all ion channels that related to synaptic plasticity. Small-conductance calcium-activated potassium channels (SKs) are found in hippocampal CA1 neurons and by inhibiting of postsynaptic potentials are involved in synaptic transmission impairment. ...