The successful application of various nanoplatforms in medicine under in vitro conditions has generated some interest in medicine-nanotechnology. The spinel-type MnZn ferrite nano powders were synthesized by Solution Combustion Synthesis (SCS) method. The important classes of soft magnetic materials Mn-Zn ferrites have high magnetic permeability and low power losses.Mn-Zn-Fe2O4 have a spinal st...

A current advance in nanotechnology is the selective targeting of therapeutics by external magnetic field-guided delivery. This is an important area of research in medicine. The use of magnetic forces results in the formation of agglomerated structures in the field region. The transport characteristics of these agglomerated structures are explored. A nonintrusive method based on in situ light-s...

Magnetic nanoparticle-mediated intracellular hyperthermia has been a largely experimental modality of hyperthermia, but this treatment modality has the potential to achieve tumor targeted heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue and then applying an external alternating magnetic field to induce heat generation by the magnetic n...

The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and mag...

the purpose of this study, determining the optimal cultivation pattern by using interval mathematical programming approach among the farmers of esfarayen county before and after targeting the subsidies. for this purpose, farmers based on water resources classified in three group of using the river water, deep wells water and rainfed cultivation. the required data for this study has been obtaine...

The prostate specific membrane antigen (PSMA) is broadly overexpressed on prostate cancer (PCa) cell surfaces. In this study, we report the synthesis, characterization, in vitro binding assay, and in vivo magnetic resonance imaging (MRI) evaluation of PSMA targeting superparamagnetic iron oxide nanoparticles (SPIONs). PSMA-targeting polypeptide CQKHHNYLC was conjugated to SPIONs to form PSMA-ta...

One of the greatest challenges in the deployment of chemotherapeutic drugs against brain tumors is ensuring that sufficient drug concentrations reach the tumor, while minimizing drug accumulation at undesired sites. Recently, injection of therapeutic agents following blood-brain barrier (BBB) opening by focused ultrasound (FUS) with microbubbles (MBs) has been shown to enhance drug delivery in ...

Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled "off-on" DDS with...

How to find early gastric cancer cells in vivo is a great challenge for the diagnosis and therapy of gastric cancer. This study is aimed at investigating the feasibility of using fluorescent magnetic nanoparticle (FMNP)-labeled mesenchymal stem cells (MSCs) to realize targeted imaging and hyperthermia therapy of in vivo gastric cancer. The primary cultured mouse marrow MSCs were labeled with am...

Magnetic metal oxide nanoparticles were conjugated to single stranded DNA (ssDNA), and Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different ways of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles ma...