Through a detailed analysis of seismicity at the base of the transition zone, we obtain an updated value of the maximum reliable depth of confirmed seismicity, we investigate regional variation in the maximum depth of seismicity among those Wadati-Benioff zones which reach the bottom of the transition zone, and we attempt to quantify the maximum possible rate of seismic release in the lower man...

This article reviews previously described methods of fresh tissue sampling from radical prostatectomy specimens for research and describes a method used in Oxford which is simple, logical and cost effective. The method utilises a systematic zonal approach to tissue procurement in order to meet the increasing requirement for research samples with detailed morphological information such as zone o...

Refractive surgery is evolving rapidly. A recent development uses wavefront aberration information to improve the surgical outcome. Before the wavefront information can be used effectively a number of problems must first be resolved. One of the main concerns is the presence of halos during night driving conditions. It seems clear that this problem occurs when the pupil is large enough to overla...

Within the FOP family of centrosomal proteins, the conserved FOR20 protein has been implicated in the control of primary cilium assembly in human cells. To ascertain its role in ciliogenesis, we have investigated the function of its ortholog, PtFOR20p, in the multiciliated unicellular organism Paramecium. Using combined functional and cytological analyses, we found that PtFOR20p specifically lo...

[1] Investigations into mechanisms driving surface tectonics commonly search for mantle sources, but few observations constrain flow in the upper mantle and transition zone. Here variations in the upper mantle discontinuities at 410 km and 660 km below the western United States are revealed through mapping depths of compressional-to-shear wave conversions recorded by broadband seismometers. The...

[1] The ice sheet–ice shelf transition zone plays an important role in controlling marine ice sheet dynamics, as it determines the rate at which ice flows out of the grounded part of the ice sheet. Together with accumulation, this outflow is the main control on the mass balance of the grounded sheet. In this paper, we verify the results of a boundary layer theory for ice flux in the transition ...

PURPOSE To identify an optimal customized ablation strategy in the treatment of eyes with secondary irregular astigmatism. METHODS Corneal anterior surface elevation maps of 50 eyes with secondary irregular astigmatism after decentered laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK) and 50 virgin eyes were used for customized ablation simulations. Two ablation simula...

Nephronophthisis (NPHP) is a hereditary cystic kidney disorder that causes renal failure in children and young adults and can be associated with various extrarenal disorders, including retinitis pigmentosa. Six NPHP genes, whose functions are disrupted by autosomal recessive mutations in patients with NPHP, have been identified. The majority of patients with NPHP carry homozygous deletions of N...

BACKGROUND In most cells, the cilium is formed within a compartment separated from the cytoplasm. Entry into the ciliary compartment is regulated by a specialized gate located at the base of the cilium in a region known as the transition zone. The transition zone is closely associated with multiple structures of the ciliary base, including the centriole, axoneme, and ciliary membrane. However, ...

To assist the analysis of tsunami hazards for Qatar coastal areas were using numerical model. By Tsunamis waves created from submarine earthquakes magnitude (Mw) 8.6 and 9.0 in Richard scale along Makran Subduction Zone (MSZ) as well landslides with soil volume 1.25 to 2.0 km3 Iranian coast inside Arabian Gulf is considered. TUNAMI-N2KISR model (Al-Salem) was applied this study predict propagat...