The importance of B cells in host resistance to, and recovery from, Cryptosporidium parvum infection was examined in gene-targeted B cell-deficient (muMT-/-) mice. Neonatal muMT-/- mice infected with C. parvum at 5 days of age completely cleared the infection by day 20 PI. The kinetics of infection and clearance were similar to those seen with age-matched C57BL/6 control mice. Furthermore, B ce...

It has been proposed that diet-induced obesity at thermoneutrality (TN; 29°C) is reduced by a UCP1-dependent thermogenesis; however, it has not been shown how UCP1-dependent thermogenesis can be activated in the absence of sympathetic activity. A recent study provides such a mechanism by showing that dietary bile acids (BAs) suppress obesity in mice fed a high-fat diet (HFD) by a mechanism depe...

introduction: several investigations have indicated that dopamine d receptors could influence morphine 2 eward. the influence of olanzapine (a d dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (cpp) in male and female mice was investigated in the present study. methods: the effects of olanzapine on the acquisition and expression of morphine cpp in male and fe...

PURPOSE To investigate the lipid and DNA oxidative stress as well as corneal and retinal effects after ultraviolet B (UV-B) exposure in mice, with or without silicon hydrogel soft contact lenses (SCL). METHODS Twenty-eight C57BL6-strain male mice were divided into four groups: group I, control group with no SCL (SCL [-]) and no UV-B exposure (UV-B [-]); group II, senofilcon A SCL (senofilcon ...

Background: Heavy metals such as cadmium (Cd2+) are natural components of the Earth's crust which can not be degraded or destroyed. Industrial, mining and agricultural activities, particularly the excessive use of phosphate fertilizers, have led to high levels of cadmium contamination at many locations worldwide. Some toxic effects of cadmium are due to its inhibition of various enzyme sys...

Abstract Background and Aims Renal complement expression has been observed in both experimental human kidney diseases. We have previously reported massive tubular C3 fibrotic TGF-beta1 transgenic mice (Nephrol Dial Transpl 2015, 30; S3:FP301). Still, little is known whether this intra-renal only an inflammatory marker of renal fibrosis or also exerts direct pro-fibrotic effects the pathogenesis...

Abstract Background Myocardial infarction (MI) is one of the prevalent causes death in world, with some patients developing heart failure from myocardial remodelling after infarction. Inflammatory processes trigger post-MI. One inflammatory factor Type 1 Interferon which can be released by cytosolic dsDNA, sensed via STING-receptor. The aim this study was to reduce response inhibiting STING-rec...

Hepatic inflammation is a key pathological feature of Nonalcoholic Steatohepatitis (NASH). Natural Killer T-cells (NKT) and CD8+ T-cells are known to play an important role in obesity related adipose tissue inflammation. We hypothesized that these same inflammatory phenotypes would be present in progressive NASH. We used a previously established high fat high carbohydrate (HFHC) murine obesogen...