Abstract Clonal evolution, the process of expansion and diversification mutated cells, plays an important role in cancer development, resistance, relapse. Although clonal evolution is most often conceived as driven by natural selection, recent studies uncovered that neutral shapes a significant proportion solid cancers. In hematological malignancies, interplay between selection also disputed. B...

Succinate dehydrogenase (SDH) is a multifaceted enzyme for the mitochondria of eukaryotes, which responsible converting succinate to fumarate as component in Krebs cycle. Its dysfunction occurs several malignancies associated with endocrine and epithelial tumors. SDH an enzymatic complex made some subunits. recognized oncometabolite; therefore, discovery mutations can give straight connection b...

EDITORIAL article Front. Oncol., 17 August 2021Sec. Hematologic Malignancies Volume 11 - 2021 | https://doi.org/10.3389/fonc.2021.744009

Relapse or refractory B-cell malignancies have been reported in multiple clinical trials after treatment of Anti-CD19 Chimeric Antigen Receptor (CAR) T-cells. Many studies demonstrated the potential immune escape mechanism for like genetic mutation, transcriptional deregulation, lineage switch, loss CAR T-cells, and trogocytosis. The study these mechanisms can provide us insights designs future...

as the data on the epidemiology and outcome of fungal infections in children with hematologic cancer are limited especially in iran, this study was aimed to delineate the epidemiologic features and outcome of fungal infections in this population. the medical records of all children with hematologic malignancies diagnosed with a fungal infection from 2005 to 2010 at a tertiary pediatric hospital...