Bone leiomyosarcoma is a rare primary osseous malignant tumor with a high metastatic potential. Similar to other bone sarcomas, high histological grade and tumor stage are predictive of a poor outcome. We herein present our experience with treating a 64-year-old woman with bone leiomyosarcoma accompanied by multiple bone metastases. A biopsy revealed occasional osteoclast-like giant cells. In a...

Background: Alterations of systemic metabolic parameters are always present vitamins in cancer in addition radiotherapy may increases and complicates these disorders. The analysis of each biochemical metabolic alterations may give more understanding to biochemistry of malignancy   and improving the degree of radiotherapy. The current study aimed to follow up the changes of folate, vitamin B12 a...

We report a rare case of malignant degeneration of a squamous papilloma to squamous cell carcinoma. A 47-year-old female presented at our tertiary referral center with squamous papilloma of the middle ear that transformed into advanced-stage (T4N0M0) squamous cell carcinoma of the temporal bone, with involvement of the facial nerve, labyrinth, temporomandibular joint, sigmoid sinus, and dura of...

Background/Aim: Osteosarcoma is the most frequent malignant bone tumor. Failure of first-line therapy results in poor prognosis osteosarcoma. In present report, we examined efficacy combination oral recombinant methioninase (o-rMETase) and docetaxel (DOC) on an osteosarcoma patient-derived orthotopic xenograft (PDOX) mouse model. Materials Methods: Osteosarcoma-PDOX models were established by t...

Chondrosarcoma is a rare malignant tumor of bone. This family of tumors can be primary malignant tumors or a secondary malignant transformation of an underlying benign cartilage tumor. Pain is often the initial presenting complaint when chondrosarcoma involves the spine. In the mobile spine, chondrosarcoma commonly presents within the vertebral body and shows a predilection for the thoracic spi...

BACKGROUND Wide resection margins of osseous tumors are associated with a low incidence of local recurrence, making accurate measurement of the intraosseous extent of primary malignant long bone tumors is crucial. We compared the intraosseous tumor extent assessed by magnetic resonance imaging (MRI) with the gross specimen to evaluate the accuracy of MRI. METHODS A total of 255 patients with ...

UNLABELLED 18F-fluoride PET/CT was performed on 44 oncologic patients to evaluate its diagnostic accuracy in assessing malignant osseous involvement and in differentiating malignant from benign bone lesions. METHODS (18)F-fluoride PET and (18)F-fluoride PET/CT were interpreted separately. Lesions showing increased (18)F-fluoride uptake were categorized as malignant, benign, or inconclusive. T...

INTRODUCTION: Bone and soft tissue sarcomas represent a small percentage of cancers worldwide; however, they are the third most children cancer in United States. Despite major advances in the treatment of advanced bone and soft tissue sarcomas such as the introduction of novel chemotherapy regimens, therapy fails in about one fourth of the patients. Therefore, to treat the patients with advance...

A 10-year-old female miniature poodle had a mass in its carpal joint of the left forelimb. The tumor was divided into small multiple lobules by delicate connective tissues, and necroses were found in some of the central lobules. In some connective stromal areas, chondroid and osteoid tissues were formed. The tumor cells were similar to the structure of apocrine gland epithelial cells with apica...

Bone marrow-derived antigen-presenting cells (APCs) play a central role in the induction of tolerance to tumor antigens expressed by B-cell lymphomas. Here we show that in vivo disruption of this APC-mediated tolerogenic mechanism unveils an intrinsic ability of malignant B cells to efficiently present tumor antigens to antigen-specific CD4+ T cells, resulting in a strong antitumor effect. This...