Aims Neuroleptic malignant syndrome (NMS) is a rare condition experienced by patients taking typical and/or atypical antipsychotic medications. There are well-established diagnostic criteria for NMS. However, differentiating it from serotonin and hyperthermia—particularly in the intensive care setting--is problematic thus remains diagnosis of exclusion. A case report patient with NMS described ...

OBJECTIVES The objective of this review is to assist the readers, anesthesiologists, intensivists, and emergency physicians in making a more accurate diagnosis of perioperative fever or hyperthermia and subsequently choose the proper course of treatment. AIM To identify the many sources of perioperative fever and after a more accurate differential diagnosis, select appropriate treatment optio...

Human malignant hyperthermia is a life-threatening genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarizing neuromuscular blocking drugs occurring during or after anaesthesia. The skeletal muscle relaxant dantrolene is the only currently available drug for specific and effective therapy of this syndrome in man. After its introduction, the mortality of malignant hyperthe...

Gliomas are one of the most common primary brain-tumors. Despite surgery and radiotherapy (RT) with or without adjuvant chemotherapy, malignant glioma remains an almost uniformly fatal disease characterized by a rapid and devastating clinical course. Deep region hyperthermia (capacitative electro-hyperthermia) as an oncological treatment in brain-glioma (BG) is applied either alone or in combin...

the superficially located stores of calcium in heart sarcolemma. In Recent Advances in Studies on Cardiac Structure and Metabolism, Vol 9, edited by Roy PE. Baltimore, University Park Press, 1976, p 53 44. Glynn IM: The action of cardiac glycosides on ion movements. Pharmacol Rev 16: 381, 1964 45. Lee KS, Klaus W: The subcellular basis for the mechanism of inotropic action of cardiac glycosides...

Background Use of extracorporal circulation (cardiopulmonary bypass) during cardiac surgery can cause a systemic inflammatory response. This so called “post-perfusionsyndrome” (PPS) occurs in about a quarter of patients and results in clinical signs and symptoms of “systemic inflammatory response syndrome” (SIRS) in 2-10% of patients. This condition is clinically associated with mild hypertherm...

BACKGROUND Between 1992 and 2011, 373 Canadian individuals with adverse anesthetic reaction were referred to the Malignant Hyperthermia Unit in Toronto, Ontario, Canada for malignant hyperthermia (MH) diagnostic testing. We analyzed the epidemiologic characteristics of the index adverse anesthetics for those probands who were confirmed to be MH susceptible. METHODS One hundred twenty-nine pro...

Control pigs required 109.9 ug/kg/min and MHS pigs required 72.4 ug/kg/min infusion of Organon 9426 to maintain a 90% block. It appears that Organon 9426 is only one-third to one-half as potent as Vecuronium in pigs. The fact that MHS pigs only require 66% of the infusion dose to maintain a 90% block suggests that there is difference in the neuromuscular effect of Organon 9426 in MHS vs. contro...