BACKGROUND AND IMPORTANCE Malignant peripheral nerve sheath tumors are the most common malignant mesenchymal tumors of soft tissues, but they are very rare when found to arise from a cranial nerve and when not in association with neurofibromatosis. These tumors are highly malignant and carry a poor prognosis with survival usually less than 6 months. CLINICAL PRESENTATION The authors report th...

Background. Carcinosarcoma is an extremely rare malignant neoplasm, with both a malignant epithelial and mesenchymal component, that rarely affects the larynx. Aim. Aim of this paper is to describe the case of a patient affected by a larynx carcinosarcoma treated by endoscopic horizontal partial laryngectomy with CO(2) laser and particularly discuss the histogenetic hypothesis as well as the po...

Carcinosarcoma of the salivary gland is an extremely rare tumor that is composed of both malignant epithelial and mesenchymal components. Diagnosing carcinosarcoma with fine-needle aspiration cytology is challenging because of its overlapping cytomorphologic characteristics with other high-grade malignant salivary gland tumors. Among the many features, including pleomorphic oncocytoid epithelia...

Aggressive Angiomyxoma (AA) is a rare, locally aggressive mesenchymal neoplasm that commonly involves the vulvoperineal region of females in reproductive age [1]. Steeper and Rosai first mentioned the term “aggressive angiomyxoma” in 1983 and considered it to be a rare benign mesenchymal tumor with a locally aggressive nature [9-11]. Aggressive angiomyxoma commonly presents as a painless, gelat...

the majority of osseous tumors of the hand are benign. the surgeon who evaluates and treats osseous tumors of the hand has to be familiar with limb anatomy, tumor biology, various presentations of the tumors and the range of treatment possibilities and their limitations. lesions in the hand more often present earlier in their course than those at other sites, just because they are more likely t...

Objectives: Bone and soft tissue tumors have become more common recognized diseases with developing medical technologies. The life span of the patients has been prolonged effective treatment methods technology. Regardless their area expertise, concept multidisciplinary tumor approach emerged in recent years, since it is difficult for a single physician to manage malignant mass process. For this...

Pleomorphic sarcomas (PS) are a heterogeneous group of poorly differentiated malignant neoplasms mesenchymal origin affecting various organs and tissues, which account for 5–7% all soft tissue tumors. PS most often affects the tissues extremities, while being extremely rare in orbital region eyeball. The final diagnosis is given after histological immunohistochemical (IHC) test supplemented by ...

Abstract Introduction Liposarcomas are malignant neoplasms that originate in fatty mesenchymal tissue and the most common histological subtype of soft sarcomas. They account for 1% solid tumors adults located mainly extremities, with retroperitoneum being second frequent location. Given rarity aggressiveness these tumors, it is advisable to establish a multidisciplinary approach towards them or...

Introduction: Differentiation of benign and malignant liver tumors is very important for finding appropriate treatment procedure. Human eyes sometime are not able to diagnose the type of liver tumor. Texture analysis is considered as a suitable method to increase the diagnostic power of medical images. In this study texture analysis is employed in order to classification of ben...

Hyaluronan (HA), a principal constituent of the extracellular matrix (ECM), mediates growth and metastasis of tumor cells. The role of HA in the epithelial-mesenchymal transition (EMT) is well known, and increased ECM remodeling is observed in mesenchymal-like cells. The HA synthesis inhibitor 4-methylumbelliferone (4-MU) is anti-tumorigenic for various malignant tumors. However, the antitumor ...