We studied the levels of twenty two free amino acids in the striatum and olfactory bulb of mice treated during nine weeks with daily intraperitoneal injections of manganese chloride at a concentration of 5.0 mg Mn+2/kg body weight. In the olfactory bulb the contents of alanine, alpha-amino-n-butyrate, arginine, asparagine, aspartate, citrulline, GABA, glutamate, glycine, isoleucine, leucine, me...

Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn(2+)) enhances MRI contrast in vivo. Due to similarities between Mn(2+) and calcium (Ca(2+)), the premise of manganese-enhanced MRI (MEMRI) is that the former may enter neurons and other excitable cells through voltage-gated Ca(2+...

Permanganate-Based Synthesis of Semiconducting Metal Oxide Nanoparticles in the Protein Ferritin Cameron Olsen Department of Physics and Astronomy, BYU Bachelor of Science This thesis investigates the reactions of Mn2+ and Co2+ with permanganate as a route for manganese and cobalt oxide nanoparticle synthesis in the protein ferritin. Permanganate serves as the electron acceptor and reacts with ...

Magnetic resonance and relative enzymatic velocity studies with the use of the paramagnetic manganese ion were carried out on creatine kinase inactivated by the specific -SH reagents iodoacetic acid and dinitrofluorobenzene and by the nonspecific reagents urea and decyl sulfate. Modification of creatine kinase at the two essential --SH groups by iodoacetic acid or dinitrofluorobenzene affected ...

Investigation of the electrochemical behavior using cyclic voltammetry and detection of [Mn(2+)(thiophenyl-2-carboxylic acid)2 (triethanolamine)] with adsorptive stripping differential pulse voltammetry. The electrochemical behavior of a manganese(II) complex [Mn(2+)(thiophenyl-2-carboxylic acid)2(triethanolamine)] (A) was investigated using cyclic and differential pulse voltammetry in an aceta...

Microbial manganese oxidation was demonstrated at high Mn concentrations (5 g/liter) in bacterial cultures in the presence of a microalga. The structure of the oxide produced varied depending on the bacterial strain and mode of culture. A nonaxenic, acid-tolerant microalga, a Chlamydomonas sp., was found to mediate formation of manganite (gamma-MnOOH). Bacteria isolated from associations with c...

Manganese and ADHD A study published in Neurotoxicology has generated discussion because it shows a link between high levels of manganese (Mn) given to rats during infancy and the development of behavioral problems similar to Attention Deficit Hyperactivity Disorder. Mn is an essential element and is currently required by law in infant formulas, but can be neurotoxic at high levels. Recent repo...

A novel S4-symmetric icosanuclear manganese metalladiazamacrocycle was synthesized using a pentadentate ligand, N-3-phenyl-trans-2-propenoylsalicylhydrazide (H3L), that has a rigid and bulky terminal N-acyl group. A 20 cyclic repeat of an--(Mn-N-N)--linkage resulted in a highly puckered diaza-bridged 60-membered icosanuclear metallamacrocycle. The steric interaction between the ligands in the c...

Environmental manganese (Mn) toxicity causes an extrapyramidal, parkinsonian-type movement disorder with characteristic magnetic resonance images of Mn accumulation in the basal ganglia. We have recently reported a suspected autosomal recessively inherited syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia in cases without environmental Mn exposure. Whole-genome mappin...

The high intracellular Mn/Fe ratio observed within the bacteria Deinococcus radiodurans may contribute to its remarkable resistance to environmental stresses. We isolated DR2539, a novel regulator of intracellular Mn/Fe homeostasis in D. radiodurans. Electrophoretic gel mobility shift assays (EMSAs) revealed that DR2539 binds specifically to the promoter of the manganese acquisition transporter...