A case of Obsessive Compulsive Disorder with no contributory or past history who developed delusional mania while on clomipramine is presented. The manic symptoms resolved after discontinuation of drug. The link between serotonin and mania is speculated upon. The need to look for manic symptoms in patients on clomipramine is stressed.

Transcranial direct current stimulation is a method of noninvasive brain stimulation (NIBS) that has been intensively investigated in the last few years [1,2]. In tDCS, a weak and continuous electrical current over the scalp is applied for several minutes. If electrodes are appropriately placed and adequate parameters of stimulation are used, tDCS changes cortical excitability significantly [3]...

The primary objective of this study was to evaluate the psychometric characteristics of the Young Mania Rating Scale (YMRS), the K-SADS Mania Rating Scale (KMRS), and the Children's Depression Rating Scale-Revised (CDRS-R) across four age groups (4-7, 8-10, 11-13, and 14-17 years). The interrater reliability of K-SADS diagnoses was also examined. Participants included 1,014 youths (62.1% male) ...

OBJECTIVE To examine the efficacy of adjunctive right prefrontal high-frequency repetitive transcranial magnetic stimulation (rTMS) treatment in adolescent mania patients as compared to sham stimulation. METHODS Twenty six right handed patients aged 12-17 years diagnosed with bipolar mania were randomized to receive daily sessions of active or sham rTMS (20 Hz, 110% of motor threshold, 20 tra...

Bipolar disorders are heritable psychiatric conditions often abstracted by separate animal models for mania and depression. The principal mania models involve transgenic manipulations or treatment with stimulants. An additional approach involves analysis of naturally occurring mania models including an inbred strain our lab has recently characterized, the Madison (MSN) mouse strain. These mice ...

OBJECTIVE Since improved prediction of illness course early in bipolar disorder is required to guide treatment planning, the authors evaluated recovery, first recurrence, and new illness onset following first hospitalization for mania. METHOD Bipolar disorder patients (N=166) were followed 2-4 years after their first hospitalization for a manic or mixed episode to assess timing and predictors...

Psychiatric disorders are like children laughing and playing gaily in the park, while behind a screen other children, dimly seen, cry out to us for help. We want to come to their aid but their shapes are like shadows. Nor do we know where they are. Bipolar disorder is like one of these children. We have it before us in the pharmaceutical advertising, the woman going up and down on the merry-go-...

Methods We review and discuss the recent evidence on the presence of mixed features during mania and depression and summarise findings on the conceptualisation of mixed states. Electronic searches of all English-language papers were performed in the MEDLINE and PUBMED database using and cross-listing key words: mixed state, mixed features, bipolar disorder, major depressive disorder, mania, hyp...

The concept of unipolar mania, unlike unipolar depression, has received relatively little attention. We review the research available on the validity of it as a separate entity. Studies show that there are few consistent differences in sociodemographic and family history variables in unipolar mania compared to other bipolar disorders, but there are a few differences regarding clinical picture, ...