INTRODUCTION As an alternative to DNA microarrays, mass spectrometry based analysis of proteomic patterns has shown great potential in cancer diagnosis. The ultimate application of this technique in clinical settings relies on the advancement of the technology itself and the maturity of the computational tools used to analyze the data. A number of computational algorithms constructed on differe...

Mammogram is measured the most consistent method for early detection of breast cancer. Computer-aided diagnosis system is also able to support radiologist to detect abnormalities earlier and more rapidly. In this paper the performance evaluation of the computer aided diagnostic system for the classification of mass classification in digital mammogram based on Discrete Wavelet Transform (DWT), S...

The discovery of activation state dependent kinase inhibitors, which bind specifically to the inactive conformation of the protein, is considered to be a promising pathway to improved cancer treatments. Identifying such inhibitors is challenging, however, because they can have Kd values similar to molecules known to inhibit kinase function by interacting with the active form. Further, while inh...

BACKGROUND Accessible public information on self-reported height and weight is not widely used in studies of obesity, mainly because of the questionable validity of body mass index (BMI) values calculated from these data. To assess the utility of self-reported measurement, we compared self-reported and standard measurements of height and weight in a Korean population that is leaner than Western...

We have developed an algorithm called Q5 for probabilistic classification of healthy versus disease whole serum samples using mass spectrometry. The algorithm employs principal components analysis (PCA) followed by linear discriminant analysis (LDA) on whole spectrum surface-enhanced laser desorption/ionization time of flight (SELDI-TOF) mass spectrometry (MS) data and is demonstrated on four r...

To satisfy the ever growing need for effective screening and diagnostic tests, medical practitioners have turned their attention to high resolution, high throughput methods. One approach is to use mass spectrometry based methods for disease diagnosis. Effective diagnosis is achieved by classifying the mass spectra as belonging to healthy or diseased individuals. Unfortunately, the high resoluti...

Meson spectra given as fluctuations of a D7 brane are studied under the background driven by the dilaton. This leads to a dual gauge theory with quark confinement due to the gauge condensate. We find that the effect of the gauge condensate on the meson spectrum is essential in order to make a realistic hadron spectrum in the non-supersymmetric case. In the supersymmetric case, however, only the...

gastrointestinal stromal tumors (gists) are rare and these tumors are mesenchymal tumors that develop in the wall of the gi tract. the aim of this study was to report a case with gist in pregnancy in western iran. a 39-year-old pregnant female (g5 p4) was admitted with a chief complaint of abdominal pain and epigastric fullness on 12 th april 2016. sonography showed gestational age of 15w+1d an...