Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nut...

Laminaria japonica Areshoung, a widely consumed marine vegetable, has traditionally been used in Korean maternal health. The present study investigated the antiobesity effects of Laminaria japonica Areshoung ethanol extract (LE) and its molecular mechanism in high-fat-diet-induced obese rats. Six-week-old Sprague-Dawley male rats were separately fed a normal diet or a high-calorie high-fat diet...

Widespread consumption of a Western diet, comprised of highly refined carbohydrates and fat, may play a role in the epidemic of hypertension. Hypertension can take origin from early life. Metformin is the preferred treatment for type 2 diabetes. We examined whether prenatal metformin therapy can prevent maternal high-fructose plus post-weaning high-fat diets-induced hypertension of developmenta...

Previous research has shown that prenatal diets rich in specific nutrients (e.g. taurine, omega-3 fatty acids) may provide protective cardiometabolic effects for adult offspring. The purpose of the current study was to investigate the potential of a prenatal-lactation diet rich in omega-3 longchain polyunsaturated fatty acids (omega-3 LC PUFAs) to improve metabolic function in offspring fed a h...

Maternal obesity and genetic background can affect the development of obesity and diabetes in offspring. Here we used selected strains of rats resistant (DR) vs. susceptible to development of diet-induced obesity (DIO) on high-energy (HE) diets to assess this issue. DR and DIO dams were fed either Chow or HE diet for 4 wk. DIO HE diet-fed dams and additional DR rats fed a palatable liquid diet ...

Objective: A clinically observable metabolic disorder often takes its root from modulation of transcriptional factors which in turn are responsible for perturbed protein expressions and their sequelae. Perinatal perturbations due to chronic prenatal exposure to a certain type of rice could predispose parents exposed to such ‘insult’ and their subsequent offsprings to metabolic diseases. Materi...

conclusions saturated fatty acids (sfas) served as a potential ligand for tlr4 and activated tlr4 signaling pathway, which might be involved in the pathogenesis. thus, sfas can accelerate the mechanism of inhibiting hbv replication in chb with nafld. objectives this study aimed to investigate whether the tlr4-mediated innate immunity stimulates the pathogenesis of chb in patients with nafld and...

This study examined how a maternal high-fat diet (HD) during lactation and exposure of offspring to isolation stress influence the susceptibility of offspring to the development of obesity. C57BL/6J mice were fed a commercial diet (CD) during pregnancy and a CD or HD during lactation. Male offspring were weaned at three weeks of age, fed a CD until seven weeks of age, and fed a CD or HD until 1...