The protective effect of the petroleum ether fraction of the indigenous drug Cardiospermum halicacabum against electroshock induced convulsions in rats was studied. Alcoholic extract of the petroleum ether fraction of Cardiospermum halicacabum in the dose of 350 mg/kg body weight was effectively reduced the extensor an flexor component of tonic convulsions in electroshock induced convulsions in...

EARLY in 1950 we treated 34 depressed patients with desoxyephedrine, in an attempt to discover whether it is comparable in efficiency to electroshock in the treatment of depression in a substantial proportion of cases. We origin ally intended to treat approximately 100 consecutive depressed patients admitted to hospital, and to compare the results with those obtained in the previous 200 consecu...

the rings considered in this article are commutative with identity $1neq 0$. by a proper ideal of a ring $r$,  we mean an ideal $i$ of $r$ such that $ineq r$.  we say that a proper ideal $i$ of a ring $r$ is a  maximal non-prime ideal if $i$ is not a prime ideal of $r$ but any proper ideal $a$ of $r$ with $ isubseteq a$ and $ineq a$ is a prime ideal. that is, among all the proper ideals of $r$,...

BACKGROUND The aim of this study was to determine the effect of ivabradine (a hyperpolarization activated cyclic nucleotide-gated channel (HCN) blocker) on the threshold for maximal electroshock (MEST)-induced tonic seizures in mice. METHODS Electroconvulsionswere produced inmice by means of a current (sine-wave, 50Hz, maximum 500 V, strength from 3-10 mA, ear-clip electrodes, 0.2-s stimulus ...

A series of new clubbed aryl oxadiazole-1,2,4-triazine derivatives (6a-l) were designed and synthesized using appropriate chemical routes. The structures to have the required structural elements for any compounds be potential anticonvulsant. Preliminary screening anticonvulsant activity was performed maximal electroshock seizure (MES), subcutaneous pentylenetetrazole-induced (scPTZ) behavioral ...

Salvia verticillata is one of the salvia species which possesses remarkable antioxidant activity. In the present study, we investigated the possible effects of hydro-alcoholic extract from Salvia verticillata plant (SVE) in various models of anxiety, depression and seizure in mice. Mice were randomly divided into control (saline), SVE-treated and standard treatment groups. The SVE-treated group...

During the last fifteen years, semicarbazones have been extensively investigated for their anticonvulsant properties. 4-(4-Flurophenoxy) benzaldehyde semicarbazone (C0102862, V102862) was discovered as a lead molecule and is being developed as a potent antiepileptic drug, with maximal electroshock (MES) ED₅₀ of i.p. 12.9 mg kg⁻¹. In MES (oral screen), this compound has a protective index (PI = ...

Some acetophenone derived bis Mannich bases (B1-B5) and piperidinols (C1, C4), which are the structural isomers of B1 and B4, and also quaternary piperidine derivative C6 were synthesized and studied for anticonvulsant activity. Of the compounds, C6 was reported for the first time. Chemical structures of the compounds were confirmed by UV, IR, 1H-NMR, 13C-NMR, mass spectra and elemental analysi...

The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice. In both models, only VPA and FLU showed signi...