Recently recharged water (defined here as <60 years old) is generally the most vulnerable part of a groundwater resource to nonpoint-source nitrate contamination. Understanding at the appropriate scale the interactions of natural and anthropogenic controlling factors that influence nitrate occurrence in recently recharged groundwater is critical to support best management and policy decisions t...

INTRODUCTION Bisphosphonates are the most widely used class of drug for inhibiting osteoclast-mediated bone loss, but their effectiveness at preventing joint destruction in rheumatoid arthritis has generally been disappointing. We examined whether the ability of bisphosphonates to induce osteoclast apoptosis and inhibit bone resorption in vitro is influenced by the cytokine receptor activator o...

Homoharringtonine (HHT) is a plant alkaloid that inhibits the elongation phase of translation that is currently in clinical trials. Because the intrinsically short-lived antiapoptotic protein myeloid cell leukemia-1 (Mcl-1) has been reported to support the survival of chronic lymphocytic leukemia (CLL) cells, we hypothesized that inhibition of protein synthesis by HHT would decrease Mcl-1 expre...

Homoharringtonine (HHT) is a plant alkaloid that inhibits the elongation phase of translation that is currently in clinical trials. Because the intrinsically shortlived antiapoptotic protein myeloid cell leukemia-1 (Mcl-1) has been reported to support the survival of chronic lymphocytic leukemia (CLL) cells, we hypothesized that inhibition of protein synthesis by HHT would decrease Mcl-1 expres...

BACKGROUND Medial collateral ligament (MCL) injuries are the second most common injury resulting in player lost time in elite-level ice hockey. PURPOSE To determine the incidence and injury characteristics of knee MCL sprain in male collegiate ice hockey players. STUDY DESIGN Case control. METHODS Athlete exposure data demographics, mechanism of injury, player position, time of injury occ...

mercury mineralization has occurred in relation with a listwaenitic type hydrothermal alteration system in tavreh area located northwest of khoy. mercury-bearing alteration zone which has an area about 0.4 km2 is situated in one of aland river upstreams. the only mercury compound found in this district is mercury sulfide (cinnabar) deposited as vein and veinlet forms. geochemical investigations...

Before remediating a site with contaminated soil or groundwater, the contaminant plume must first be characterized. This involves sampling the contaminant concentration at a set of locations in and around the contaminated area. To present the measured concentrations in a meaningful form, the concentrations are typically interpolated to the nodes of a three-dimensional grid and the plume is visu...

Infectious pancreatic necrosis virus (IPNV), a member of the virus family Birnaviridae, causes an acute, contagious disease in a number of economically important fish species. CHSE-214, a Chinook salmon embryonic cell line, when infected by IPNV showed morphological and biochemical features of apoptosis, including an intense DNA laddering pattern and blebbing of the plasma membrane, followed by...

MCL-1 (myeloid cell leukemia-1), a member of the BCL-2 family, has three splicing variants, antiapoptotic MCL-1L, proapoptotic MCL-1S, and MCL-1ES. We previously reported cloning MCL-1ES and characterizing it as an apoptotic molecule. Here, we investigated the molecular mechanism by which MCL-1ES promotes cell death. MCL-1ES was distinct from other proapoptotic BCL-2 members that induce apoptos...

The balance between cell cycle progression and apoptosis is important for both surveillance against genomic defects and responses to drugs that arrest the cell cycle. In this report, we show that the level of the human anti-apoptotic protein Mcl-1 is regulated during the cell cycle and peaks at mitosis. Mcl-1 is phosphorylated at two sites in mitosis, Ser64 and Thr92. Phosphorylation of Thr92 b...