Subsequently to the publication of above article, a concerned reader drew authors’ attention that, with invasion and migration assay data shown in Fig. 4A on p. 1197, there were two pairs apparently overlapping panels featured this figure (specifically, ‘MCF‑7/Invasion’ ‘huMSC+MCF‑7/Invasion’ panels, ‘huMSC+MCF‑7/Migration’ ‘huMSC/Vector/Migration’ panels). After having consulted their or...

OBJECTIVE This study aimed to investigate the cytotoxicity, apoptosis induction, and mechanism of action of steviol on human breast cancer cells (Michigan Cancer Foundation-7 [MCF-7]). MATERIALS AND METHODS Sulforhodamine-B assay was performed to analyze cytotoxic potential of Steviol whereas flow cytometer was used to analyze cell cycle, apoptosis, and reactive oxygen species generation. R...

Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) was initially identified as a gene amplified and overexpressed in breast carcinoma. The present study investigated the expression and anti-apoptotic function of TRAF4 in human breast cancer MCF-7 cells. TRAF4 was found to be localized in the cytoplasm and nuclei of MCF-7 cells by immunofluorescence staining and western blotting. T...

Lack of selectivity in the killing of tumor and normal cells is a major obstacle in cancer therapy. By inhibiting normal but not autonomous cell growth, we exploited the differences in cell cycle regulation to achieve a selective protection of nonautonomous cells against paclitaxel and other microtubule-active drugs. Tubulin polymerization, a primary effect of paclitaxel, can be dissociated fro...

Objective: Cancer chemoprevention with phytochemicals such as “lutein” derived from the vegetable okra could prove beneficial. Therefore, objective of this study was to perform a meta-analysis against breast cancer cell lines (MCF-7) and establish possible development lutein based nutraceuticals.
 Methodology: A literature survey performed using online data bases PubMed, Google scholar, EM...

OBJECTIVE Tamoxifen is currently used for the treatment of estrogen receptor-positive breast cancer patients, but acquired resistance to tamoxifen is a critical problem in breast cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is a prototype of the newly developed HDAC inhibitor. The aim of this study is to investigate the anticancer effects of SAHA in tamoxifen-resistant MCF-7 (TAMR/MCF...