Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a proliferation of multipotential stem cells in the bone marrow, and an expansion...

onstrated that the orifice and lumen of the right middle lobe bronchus were significantly obstructed by an irregular mass ( fig. 2 ). There were no mediastinal or pleural abnormalities. Bronchoscopy revealed a large gray mass subtotally obstructing the right middle lobe bronchus ( fig. 3 ). This was biopsied without incident. Histopathological examination showed sheets of spindle-shaped, pleomo...

The aim of the present study was to examine the influence of technetium methylenediphosphonate (99Tc-MDP) on the proliferation and differentiation of human osteoblasts. Human iliac cancellous bone was isolated and cultured with either 99Tc‑MDP, β fibroblast growth factor (as a positive control) or medium only (as a negative control). Proliferation was assessed by direct cell counting, CCK‑8 ass...

Received 4/8/2008; revised 7/3/2008; accepted 7/7/2008. For correspondence and reprints contact: Nan-Tsing Chiu, M.D., Department of Nuclear Medicine, Medical College, National Cheng Kung University. 138 ShengLi Road, Tainan 704, Taiwan. Tel: (886)6-2353535 ext. 2474, Fax: (886)62766609, E-mail: [email protected]. We present the case of a 71-year-old man experiencing sudden onset of consc...

abstract background: osteoid osteoma is a benign bony neoplasm and its classic treatment is surgery. in the r ecent decades percutaneous laser therapy was suggested to be replaced by surgery. in this study we have reviewed the results of the first applications of interstitial laser photocoagulation (ilp) for treatment of osteoid osteoma in iranian patients. materials and methods: in this case s...

Bone scan in diagnosis of infectious osteoarthritis  Bone scan with Technezium 99m is harmless methodoi evaluation of Skeletal lesions.It is safe 1n pedia­_ trics age group and it can be used in early diffe-rentiate osteomyelitis from cellulits sand also it may help in diagnosis of subsclinical  involvement of  eumatoid arthritis,benign and malignant bone  tumors stress fractures and periostit...

Titanium-aluminum-vanadium (Ti-6Al-4V) implants were placed in the tibiae of 32 rats (male Sprague-Dawley, 350 g) to examine healing and bone response. Half of the implants were treated with fibroblast growth factor 1 (FGF-1) delivered in an activated fibrinogen matrix. Animals were injected with a radiopharmaceutical imaging agent, technetium-99m-methylene diphosphonate (Tc-99m-MDP), which con...

Background: Skeletal uptake of 99mTc labelled methylene diphosphonate (99mTc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99mTc-MDP. Methods: 22 postmenopausal women (52–80 years) volunteered to participate. Scintigraphy was p...

A 52-year-old woman with nonspecific left leg pain was examined by Tc-99m methylene diphosphonate (MDP) bone scintigraphy. The patient had been a marble quarry worker for 10 years and had developed chronic congestive heart failure secondary to pneumoconiosis. Her hemoglobin analysis and hematologic findings were interpreted as being consistent with sickle cell beta+ thalassemia and also hypersp...