Tacrolimus and cyclosporine in the microemulsion formulation Neoral have demonstrated improvements in acute rejection rates after renal transplantation compared with conventional cyclosporine formulation, Sandimmune. To evaluate whether these drugs are also associated with improvements in chronic allograft failure (CAF) rates, we retrospectively analyzed 32,040 primary renal allograft recipient...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

Abstract We analyse the all-pay auction with incomplete information and variance-averse bidders. characterise unique symmetric equilibrium for general distributions of valuations any number Variance aversion is a sufficient assumption to predict that high-valuation bidders increase their bids relative risk-neutral case while low types decrease bid. Considering an asymmetric two-player environme...

The mean meridional circulation of the atmosphere is presented using the mass (more specifically, the pressure corresponding to the mass) above the isentrope of interest as the vertical coordinate. In this vertical coordinate, themass-weightedmean circulation is exactly balanced by entropy sources and sinks with no eddy flux contribution as in the isentropic coordinate, and the coordinate can b...