Measles virus infection induces a profound immunosuppression that may lead to serious secondary infections and mortality. In this report, we show that the human cortical thymic epithelial cell line is highly susceptible to measles virus infection in vitro, resulting in infectious viral particle production and syncytium formation. Measles virus inhibits thymic epithelial cell growth and induces ...

BACKGROUND A large measles outbreak occurred in Italy in 2002-2003. This study evaluates the health burden and economic impact of measles-related hospitalizations in Italy during the specified period. METHODS Hospital discharge abstract data for measles hospitalizations in Italy during 2002-2003 were analysed to obtain information regarding number and rates of measles hospitalizations by geog...

A prospective immunogenicity trial of measles and rubella vaccines was conducted in Oman. Children received measles vaccine at age 9 months and measles-rubella vaccine at age 15 months. Serum specimens were tested for measles-specific IgG and rubella-specific IgG. Of 1025 eligible infants, 881 (86.0%) returned for all five visits and had adequate serum samples for testing. Seroconversion to mea...

measles is a highly contagious viral disease that remains an important cause of mortality among children despite the availability of a safe and effective vaccine around the world. we aimed this study to show a measles out-break occurring.in early 2012, a report of measles outbreak was recorded on center for disease control (cdc) of fars province, south of iran. with this case-series study, char...

The typical clinical presentation of measles in a normal immunocompetent host includes cough, coryza, conjunctivitis, Koplik's spots, and rash. However, in an immunocompromised host, measles may have an atypical clinical presentation and may be commonly associated with severe pneumonia or encephalitis. We report a fatal case of measles pneumonia without any clinical features that suggest measle...

To describe the epidemiology of measles in Oman and the implications for a vaccination programme, we conducted a retrospective record-based study from 1 January 2000 to 31 December 2003 using data from the national epidemiological surveillance system. All cases notified as suspected measles during the study period were included. Of the 185 notified cases, 19.4% were confirmed measles positive. ...

Analysis of urine specimens by using reverse transcriptase-PCR was evaluated as a rapid assay to identify individuals infected with measles virus. For the study, daily urine samples were obtained from either 15-month-old children or young adults following measles immunization. Overall, measles virus RNA was detected in 10 of 12 children during the 2-week sampling period. In some cases, measles ...

During a resurgence of measles in São Paulo, Brazil, in 1997, >40,000 cases (peak incidence rate of 246/100,000 inhabitants) and 42 measles-related deaths were reported. Reverse transcriptase-polymerase chain reaction and nucleotide sequencing were used to analyze specimens from patients who had typical clinical measles infection during this outbreak and from six patients who had had measles in...

In Slovenia, where measles virus had not been circulating for many years, an outbreak of measles among visitors of an international dog show occurred in November 2014. We identified 23 measles cases plus 21 presumable secondary and tertiary cases. Thirty-nine cases were adults, 27 to 56 years-old, 12 of them vaccinated with two doses. Five were unvac-cinated children. Thanks to high vaccination...

BACKGROUND Measles remains a significant cause of vaccine-preventable mortality in sub-Saharan Africa, yet few studies have investigated risk factors for measles mortality in regions of high human immunodeficiency virus type 1 (HIV-1) prevalence. METHODS Between January 1998 and July 2003, children with clinically diagnosed measles who were hospitalized at the University Teaching Hospital in ...