Few studies in wild animals have assessed changes in mineral profile in long bones and their implications for mechanical properties. We examined the effect of two diets differing in mineral content on the composition and mechanical properties of femora from two groups each with 13 free-ranging red deer hinds. Contents of Ca, P, Mg, K, Na, S, Cu, Fe, Mn, Se, Zn, B and Sr, Young's modulus of elas...

Periostin (a product of Postn gene) is a matricellular protein which is increased in periosteal osteoblasts and osteocytes upon mechanical stimulation. We previously reported that periostin-deficient mice (Postn(-/-)) have low bone mass and a diminished response to physical activity due to a lack of sclerostin (a product of Sost gene) inhibition by mechanical loading. Here we hypothesized that ...

Bones are the principal structural components of a skeleton; they play unique roles in the body providing its shape maintenance, protection of internal organs and transmission of forces. Ultimately, their structural integrity is vital for the quality of life. Unfortunately, bones can only sustain loads until a certain limit, beyond which they fail. Understanding a fracture behaviour of bone is ...

BACKGROUND Areal bone mineral density is predictive for fracture risk. Microstructural bone parameters evaluated at the appendicular skeleton by high-resolution peripheral quantitative computed tomography (HR-pQCT) display differences between healthy patients and fracture patients. With the simple geometry of the cortex at the distal tibial diaphysis, a cortical index of the tibia combining mat...

INTRODUCTION Cortical bone is an anisotropic material, and its mechanical properties are determined by its composition as well as its microstructure. On the microstructure level (a few microns), cortical bone is composed primarily of single osteons and interstitial lamellae. Nanoindentation has been shown to be an effective technique to probe mechanical properties of microstructures at the micr...

Bone strength, which is resistance to fracture, depends not only on the bone mass, but also on its spatial distribution (microand macroarchitecture) and the intrinsic properties of the materials that constitute the bone [1]. A particular feature of the bone is the ability to adapt its size and shape in response to mechanical loads, through the process of modeling achieved by the independent act...

Osteoporosis is a disease affecting bones which characterized by decreased bone density; become porous and susceptible to fractures. occurs because of an imbalance during remodeling phase between resorption formation processes. This study aims simulate the effects mechanical stimulations on femoral elasticity limit. It hoped that these stimuli can provide information limits. Initially, we const...

UNLABELLED PURPOSE OF THE STUDY In a long-term perspective, it is better to remove implants after fracture healing. However, subsequent full or excessive loading of an extremity may result in refracture, and the bone with holes after screw removal may present a site with predilection for this. The aim of the study was to find ways of how to decrease risk factors for refracture in such a case. T...