Mechanical coupling between a cell and substrate relies on focal adhesions, clusters of adhesion proteins linking stress fibers (bundles of actin proteins) inside the cell with surrounding tissue. Focal adhesions have been demonstrated to both measure and regulate the mechanical traction along the stress fibers. We present a quantitative model for focal adhesion mechano-sensing and stress regul...

introduction: human adipose-derived mesenchymal stem cells (hadscs) are easily accessible in the body, and under appropriate conditions, they can be directed toward various phenotypes. therefore, hadscs have been considered as a potential cell source for tissue engineering applications. hadscs are able to differentiate into endothelial cells which covers the interior surface of vessels, in vivo...

Mechanical stress plays a key role in the development of cartilage degradation in osteoarthritis (OA). Nevertheless, the role of long noncoding RNAs in mechanical stress-induced regulation of chondrocytes remains unclear. The aim of this study was to explore the function of mechanical stress-related long noncoding RNAs in cartilage. Tissue samples were collected from 50 patients and chondrocyte...

The present study was designed to investigate whether apoptosis occurs in early-stage vein grafts and to determine the mechanisms by which mechanical stress contributes to apoptosis in vascular smooth muscle cells (SMCs). Apoptosis in vessel walls of mouse vein grafts was confirmed by morphological changes and by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNE...

background: mesenchymal stem cells (mscs) are multipotent cells, capable of differentiating into different cell lines.they can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. therefore, the exposure of these cells to endothelial growth factor (vegf) as well as hemodynamic biomechanical forces, which act on...