Cox, ROBERT I-3. InfIuence of chloralose anesthesia on cardiovascular function in trained dogs. Am. J. Physiol. 223(3): 660-667. 1972.The acute hemodynamic responses to chloralose anesthesia were determined in nine trained, chronically instrumented mongrel dogs. They were instrumented for the measurement of ascending aorta pressure and blood flow, and left ventricular and central venous pressur...

Mechanosensation requires the transduction of mechanical stimuli into neuronal impulses. It encompasses not only the sense of touch but also proprioception and hearing. In contrast to sight, smell and taste, relatively little is known about the molecular machinery of mechanosensation. It is already clear, however, that important aspects are conserved across phyla, from Caenorhabditis elegans to...

Mutations in the no-mechanoreceptor-potential A (nompA) gene, which eliminate transduction in Drosophila mechanosensory organs, disrupt contacts between neuronal sensory endings and cuticular structures. nompA encodes a transmembrane protein with a large, modular extracellular segment that includes a zona pellucida (ZP) domain and several plasminogen N-terminal (PAN) modules. It is specifically...