BACKGROUND The evaluation of infant meconium as a cumulative matrix of prenatal toxicant exposure requires comparison to established biomarkers of prenatal exposure. METHODS We calculated the frequency of detection and concentration of tobacco smoke metabolites measured in meconium (nicotine, cotinine, and trans-3'-hydroxycotinine concentrations) and three serial serum cotinine concentrations...

OBJECTIVES To determine the effect of clear liquor and meconium stained liquor on mode of delivery, and to evaluate neonatal outcome. METHODS It was a Cross sectional analytical study, conducted in the department of Obstetrics and Gynaecology, Shaikh Zyed Federal Postgraduate Medical Institute/Hospital, Lahore and Shaikh Zaid Women Hospital Larkana, from April 2006 to March 2007. Two hundred ...

Although the pathway for fetal defecation exists, this does not usually occur. In most cases the first defecation occurs postnatally; the bile-stained fecal matter is called meconium. In 10 15% of all deliveries, the neonate's amniotic fluid is meconium-stained, indicating some amount of in utero defecation. Even though about one-third of such neonates will have some meconium in their lungs, on...

PURPOSE To investigate the prevalence of paralytic ileus after spinal operation in the supine or prone operative position and to determine the efficacy of prophylactic gastrointestinal motility medications in preventing symptomatic paralytic ileus after a spinal operation. MATERIALS AND METHODS All patients received spinal surgery in the supine or prone operative position. The study period wa...

Earlier work form this laboratory showed that exposure of alveolar epithelial cells (AECs) to meconium caused significant cell detachment and that meconium-induced detachment of cells was prevented by a protease inhibitor cocktail. Therefore, it was hypothesized that protease inhibitors might protect AEC monolayers against meconium-induced collapse of epithelial barrier function both in vitro a...

BACKGROUND We investigated agreement between self-reported prenatal alcohol exposure (PAE) and objective meconium alcohol markers to determine the optimal meconium marker and threshold for identifying PAE. METHODS Meconium fatty acid ethyl esters (FAEE), ethyl glucuronide (EtG), and ethyl sulfate (EtS) were quantified by LC-MS/MS in 0.1 g meconium from infants of Safe Passage Study participan...

BACKGROUND Green-stained amniotic fluid does not always indicate that meconium was passed in utero. CASE PRESENTATION We report the case of a 2280-g Hispanic preterm female born at 32 weeks of gestation with congenital jejunal atresia. The amniotic fluid was greenish stained; the initial impression was meconium-stained amniotic fluid. Postnatal findings revealed no meconium in her rectum. The...

Meconium periorchitis is a bizarre albeit rare extraabdominal sequel of fetal meconium peritonitis; ensuing the passage of meconium into the scrotum via a patent processus vaginalis. We hereby present the case of a 20 day old male neonate with the sonographic, peroperative and histopathological correlates of Meconium Periorchitis. The scrotal meconium being predestined for calcification and res...