Cleft lip, which results from impaired facial process growth and fusion, is one of the most common craniofacial birth defects. Many genes are known to be involved in the etiology of this disorder; however, our understanding of cleft lip pathogenesis remains incomplete. In the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion. Mice carrying compound mutation...

Congenital cleft-Lip and cleft palate has been the subject of many genetic studies, but until recently there has been no consensus as to their modes of inheritance. In fact, claims have been made for just about every genetic mechanism one can think of. Recently, however, evidence has been accumulating that favors a multifactorial basis for these malformations. Cleft lip and palate (CLP) are bir...

objective(s:cleft lip/palate are common congenital anomalies, affecting approximately 2/1000 live births. pierre robin sequence is a subgroup of the cleft palate population. chromosomal abnormalities near the sox9 gene disrupt the regulation of this gene and prevent the sox9 protein from properly controlling the development of facial structures, which leads to isolated prs. the present study wa...

objective(s):we investigated the influence of genetic variation of the transforming growth-factor alpha (tgfa) locus on the relationship between smoking and oral clefts. materials and methods:in this study 105 iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...

OBJECTIVE The aim of the present study was to determine the morphological differences in the base of the skull of individuals with cleft lip and palate and Class III malocclusion in comparison to control groups with Class I and Class III malocclusion. METHODS A total of 89 individuals (males and females) aged between 5 and 27 years old (Class I, n = 32; Class III, n = 29; and Class III indivi...

We studied prospectively 800 paediatric patients undergoing repair of cleft lip and palate to determine the predictors of difficult laryngoscopy. The incidence of difficult laryngoscopy (Cormack and Lehane grade III and IV) was 2.95% in patients with unilateral cleft lip, 45.76% in bilateral cleft lip and 34.61% in patients with retrognathia. Tracheal intubation was successful in 99% of patient...

STATEMENT OF THE PROBLEM Individuals with oral clefts exhibit considerably more dental anomalies than individuals without clefts. These problems could initially be among the symptoms of their disease and/or they may be the side effect of their treatments. Pushback palatoplasty could cause some interference during the development of teeth and result in tooth defects. PURPOSE The study was perf...

OBJECTIVES The authors performed a systematic review and meta-analysis to investigate the possible correlation between ambient air pollution and orofacial cleft anomalies in newborns. MATERIAL AND METHODS A literature search was performed using the PubMed and Google Scholar, using the keywords "air pollution", "cleft lip", "cleft palate", "carbon monoxide", "ozone", "sulfur dioxide", "nitroge...

Facial cleft is the second most common congenital deformity. Problems of cleft can be related to esthetic, phonetics, functional insufficiency, emotional, psychological and social. Significant abnormality in nasal cartilage morphology and asymmetry of alar base and columella are associated with cleft lip and alveolar deformity. Pre Nasoalveolar molding (PNAM) is a nonsurgical method of reshapin...