Immunity to reinfection in the genital tract of female guinea pigs with the agent of guinea pig inclusion conjunctivitis was found to be dependent upon an intact humoral immune response. Cell-mediated immunity in the absence of humoral immunity had no apparent role in resistance to challenge infection.

Helicobacter bacteria colonize in the stomach and induce strong, specific local and systemic humoral and cell-mediated immunity. Helicobacter binds to the host epithelial cells, directly triggering the recruitment of neutrophils. Local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked ...

turnips with a long history of usage, are helpful in preventing breast and prostate cancer, inflammation and body`s immune system dysfunction. in this study, we investigated the effects of chloroform, ethyl acetate and methanolic extracts of brassica rapa l. on cell-mediated immune response in mice. chloroform, ethyl acetate and methanolic extracts of b. rapa glands were prepared by maceration ...

It is critically important for plants to control the trade-off between normal growth and pathogen immunity. However, underlying molecular mechanism remains largely unknown. Here we report such a controlled by WRKY70 its partner CHYR1 in Arabidopsis. We found that both levels of target gene SARD1 phosphorylated forms were increased WRKY70OE upon Pst DC3000 infection. Mechanistically, phosphoryla...

Abstract STAT3 is considered an oncogene in multiple human cancers. However, its direct involvement dendritic cell (DC)-mediated antitumor immunity and immune checkpoint blockade (ICB) remains unknown. Here, we found that was constitutively activated DCs restrained DC function the tumor microenvironment (TME). Genetic ablation of resulted enhanced T immunity, thereby slowing down progression be...

Concomitant tumor immunity describes immune responses in a host with a progressive tumor that rejects the same tumor at a remote site. In this work, concomitant tumor immunity was investigated in mice bearing poorly immunogenic B16 melanoma. Progression of B16 tumors did not spontaneously elicit concomitant immunity. However, depletion of CD4(+) T cells in tumor-bearing mice resulted in CD8(+) ...

Phytophthora spp. secrete vast arrays of effector molecules during infection to aid in host colonization. The crinkling and necrosis (CRN) protein family forms an extensive repertoire candidate effectors that accumulate the nucleus perturb processes required for immunity. Here, we show CRN12_997 from capsici binds a TCP transcription factor, SlTCP14-2, inhibit its immunity-associated activity a...

Abstract Gut microbiota is now recognized as a key player impacting the host’s anti-cancer immunosurveillance and ability to respond immunotherapy. Its optimal modulation for preventive therapeutic purposes very appealing. Since diet one of most powerful modulators microbiota, nutritional interventions could be leveraged improve host immunity. The present study aims analyze anticancer propertie...