This review summarizes the in vitro and in vivo medicinal chemistry investigations for piperazine and morpholine analogues. Piperazine and morpholine nucleus show a broad spectrum of pharmaceutical applications, thus, in recent years, scientists has developed various new methods for the synthesis of their derivatives. This review shows current tendency in the piperazine and morpholine analogues...

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In both lead identification and lead optimization processes there is an acute need for new organic small molecules. Traditional methods of organic synthesis are orders of magnitude too slow to satisfy the demand for these compounds. The fields of combinatorial and automated medicinal chemistry have been developed to meet the increasing requirement of new compounds for drug discovery; within the...

Pakistan has a variety of herbs and medicinal plant resources, due to its varied ecological conditions. Large number of physicians of south Asia (locally called Hakeems and Tib-e-Unani or Ayurvedic medicines) use herbs, plant parts and extracts for treating human diseases. Source of medicinal plants are hilly areas, deserts and coastal zones of the country. Major supply of medicinal herbs is wi...

An ethnobotanical survey was carried out in the former Transkei homeland to document the unwritten knowledge related to traditional uses of medicinal plants. The indigenous people of Transkei, Eastern Cape, South Africa depend on the natural plant resources from their environment for medicine, food, pastoral, cultural and religious needs. This area, mainly inhabited by the Xhosa people, has rem...

The current status of medicinal plants used by traditional Vaidyas was studied in Uttaranchal state of India. Information was gathered using semi-structured questionnaires among 60 traditional Vaidyas. They were questioned about the types of ailments treated with plants and the preparation of herbal medical formulations. A total of 243 herbal medical formulations prepared by Vaidyas treating 73...

The use of medicinal plants is continually expanding worldwide. The increasing search for therapeutic agents derived from plant species is justified by the emergence of diseases, yet without proper treatment, and the growth of scientific knowledge about the herbal medi‐ cines as important treatment alternatives. Therefore, the quality and safety of herbal prepa‐ rations are also of great concer...

Skin diseases are most common form of infections occurring in people of all ages. The aim of the study is not only to prescribe remedies for skin diseases in human beings but also to draw attention for the need towards a detailed study on medicinal plants, which could provide novel remedies leads for other dreadful diseases. This review has highlighted the role and utilities of some medicinal p...

Ethnobotanical studies on traditional medicinal plants were conducted in Ba To district and documented different types of traditional medicinal plants used by the indigenous peoples. The study was focused on identifying medicinal plants, distribution, disease treated, part of the plant used, and methods of preparation... A total 45 species of medicinal plants (belonging to 26 families) were col...

1 The Department of Chemistry, Georgia State University, Atlanta, GA 30302, USA 2 College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China 3 The Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, OH 43210, USA 4 The Department of Chemistry, University of South Carolina Salkehatchie, Walterboro, SC 29488, US...