Cutaneous pigmentation is a well-recognized feature of idiopathic haemochromatosis and, in various series, has been recorded in up to 8o per cent. of patients (Finch and Finch, I955). In the world literature there are occasional reports of pigmentation in the gums (Saundby, I890), buccal mucous membranes (Richardiere, I895), lips (Parker, I903), and tongue (Hess and Zurhelle, I905), and Maddox ...

To provide better customer service, NCJRS has made this Federally-funded grant final report available electronically in addition to traditional paper copies. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. 1. Abstract The overall goal of this research project was to determine with a high degree of accur...

Cutaneous pigmentation is a well-recognized feature of idiopathic haemochromatosis and, in various series, has been recorded in up to 8o per cent. of patients (Finch and Finch, I955). In the world literature there are occasional reports of pigmentation in the gums (Saundby, I890), buccal mucous membranes (Richardiere, I895), lips (Parker, I903), and tongue (Hess and Zurhelle, I905), and Maddox ...

Melatonin, the evolutionarily ancient methoxyindoleamine, has long captured attention of investigators since discovery its regulation mammalian fur and amphibian skin pigmentation, as well extrapineal synthesis receptor expression in human skin. Yet, melatonin’s role impact on melanocyte physiology remain unclear. Therefore, we asked whether melatonin stimulates or inhibits epidermal pigmentati...

Melanocytes are an important component of skin pigmentation through their ability to produce melanin assisted by the enzyme tyrosinase which is a core in melanogenesis. The high phenolic and flavonoid compounds leaves, seeds avocados have potential as ligands (inhibitors) related protein-1. This study aims determine active from seeds, that play role inhibiting activity humans so it can inhibit ...

1. The dormant eggs of Daphnia (Crustacea: cladocera) are encased in a protective, chitonous casing known as an ephippium. Ephippia are pigmented with melanin, and the degree of pigmentation ranges from transparent to opaque. Variation in pigmentation exists within and across populations and species, raising questions about the factors that influence the natural distribution of pigmentation. 2....

Variation in human pigmentation has long been an area of interest in biological anthropology, with the advent of genetic technologies allowing deeper plumbing of its evolutionary history. Genome-wide scans of selection show that pigmentation genes have undergone some of the strongest selection in many geographically distant populations. A variety of hypotheses for the photoprotective effects of...

Oral postinflammatory pigmentation (OPP) is a discoloration of the oral mucosa caused by an excess of melanin production and deposition within the basal layer of the epithelium and connective tissue of areas affected by chronic inflammation. Therefore, it is mandatory to demonstrate the association with a previous or concomitant inflammatory process in the same area of oral mucosa. Clinically O...

Skin color is determined by epidermal melanin content, the function of which remains poorly understood. Clinically, there is a lower incidence of melanoma in individuals with high levels of constitutive brown/black pigment and/or acquired pigmentation (i.e. tanning). Conversely, individuals with red hair, blue eyes, and inability to tan are at higher risk for developing melanoma. Therefore, pig...

Melanocytes are cells specialized in the synthesis of the pigment melanin, in the form of eumelanin, the brown/black, and pheomelanin, the red/yellow pigment (Ito and Wakamatsu 2003). Melanocytes reside in the cutaneous epidermis, within hair follicles, in the eye, the leptomeninges, the inner ear, and as has been demonstrated lately, in the heart (Brito and Kos 2008; Goldgeier et al. 1984; Tac...