BACKGROUND Melasma treatment remains challenging despite various laser systems available, because of potential side-effects and high recurrence rates. OBJECTIVE Non-ablative fractionated photothermolysis (FP) is a promising therapeutic method, long-time results comparing treated vs. non-treated site are lacking. METHODS A total of 14 patients were treated with FP in a split-face mode with s...

BACKGROUND Melasma is a common pigmentary disorder that remains resistant to available therapies. Facial resurfacing with the pulsed CO2 laser has been reported successful but requires significant downtime, and there is a risk of adverse sequelae. OBJECTIVE To determine if melasma will respond to a new treatment paradigm, fractional resurfacing. METHODS Ten female patients (Fitzpatrick skin...

Aim: To compare the efficacy and safety of topical 3% tranexamic acid gel vs 35% glycolic peel in treatment melasma over face.
 Materials Methods: This is an open labelled, Randomised Controlled Trial(RCT) conducted on 60 patients. Patients were randomly divided equally into 2 groups – Group A B. used twice a day B patients treated with contact period 5 minutes once every weeks. assessed m...

Abbreviations: BC: Before Christ; UV: Ultraviolet; NCBI: National Center For Biotechnology Information; Mirna: Microrna; IL-1: Interleukin 1; MSH: Melanocyte Stimulating Hormone; ACTH: Adrenocorticotropic Hormone; LH: Luteinizing Hormone; FSH: Follicle-Stimulating Hormone; MC1R: Melanocortin Type 1 Receptor; ER: Estrogen Receptor ; PR :Progesterone Receptor; TPO: Thyroid Peroxidase; TSH: Thyroi...

*Corresponding author: Dr. Ilaria Muller, Clinical Lecturer, Centre for Endocrine and Diabetes Sciences, Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine, Room 256, main building block C, second floor (C2 Link Corridor), University Hospital of Wales Heath Park, Cardiff, CF 14 4XN, UK, Tel: Tel: +44(0)29 2074 2182; Fax: +44(0)29 2074 4671; E-mail: ilaria.mull...

Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Whitening agents act at various levels of melanin production in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme ...

Abnormal pigmentation is related to a variety of cosmetic and clinical conditions including melasma, lentigo, age spots, vitiligo, etc. Numerous actives designed to modulate skin tone have been utilized as cosmetics and pharmaceuticals to address these conditions. We report on an optimized short-term (1-week) protocol using the Asian MelanoDermTM model (MatTek Corporation) and designed to rapid...

Melasma is one of the most prevalent acquired pigmentation disorders, especially among women due to its hormonal background. There a wide variety therapeutic alternatives available for treatment given multifactorial origin and complexity. Cosmetic protocols based on depigmenting agents remain cornerstones melasma treatment. Aim: To evaluate efficacy safety new cosmetic pigment correction protoc...