Indomethacin (IND) is one of the supporting drug candidates for colonic targeting but it belongs to BCS class II category presenting a challenge in optimal at site. To overcome this challenge, we sought prepare pH-dependent soluble ternary solid dispersion (SD) IND improved solubility and dissolution rate colon without need coating. The current study focuses on preparation binary SDs API with s...

The numerical dimensioning of injection heads and tools for the extrusion of rubber profiles requires both, the experimental investigation and numerical consideration of the viscoelastic material behavior. Usage of finite element software allows drastic reduction of a time-consuming empiric adaptation process for the design of extrusion tools. In this context, viscoelasticity covers three diffe...

Behaviour in a Dynamic In Vitro Dissolution Model A. Goyanes, H. Chang, A. Buanz, J. Wang, S. Gaisford, A. W. Basit University College London Purpose 3-dimensional printing (3DP) is a new technology which could potentially revolutionise the future of pharmaceutical manufacturing. In fused-deposition modelling (FDM) printing, a polymer filament is heated and extruded through a small tip and soli...

Extrusion-based additive manufacturing (EAM) is a relatively new process developed for the production of complex metallic and ceramic parts needed in smaller quantities. The debinding sintering step EAM adopted from well-known powder injection molding process. However, 3D printing needs special consideration to make competent era rapid manufacturing. This study intended investigate effect commo...

In this study, the effect of calcium (Ca) and erbium (Er) on microstructure, mechanical properties, corrosion behavior magnesium-zinc alloys is reported. The were prepared using disintegrated melt deposition (DMD) technique alloying additions as Zn, Ca, Mg-Er master followed by hot extrusion. Results show that addition Er has significantly reduced grain sizes Mg-Zn also when compared to pure ma...

Abstract. In this research, four novel types of hyperbranched polyester polymers (HBPs) were used and blended with polypropylene polymer PP, virgin VPP recycled rPP, using a twin-screw extrusion machine. Hyperbranched was added in different weight ratios (5%, 10%, 20%). The Fourier transform spectroscopy FTIR, the water contact angle CA, biodegradation soil, rheological properties (melt flow ra...

The demand for aluminum alloys is increasing, as are the demands higher strength, with aim of using lighter products a greener environment. To achieve high-strength, corrosion-resistant alloys, melt rapidly solidified melt-spinning technique to form ribbons, which then plastically consolidated by extrusion at elevated temperature. Different chemical compositions, based on adding transition-meta...