نتایج جستجو برای: membrane crystallization
تعداد نتایج: 411323 فیلتر نتایج به سال:
By the use of limited trypsin digestion of purified virions, we generated a membrane anchor-free and crystallizable form of the tick-borne encephalitis virus envelope glycoprotein E. It retained its reactivity with a panel of monoclonal antibodies, and only subtle structural differences from the native protein E were recognized. Treatment with the bifunctional cross-linker dimethylsuberimidate ...
in this study, the effect of recrystallization of naproxen in the presence of hydroxypropyl cellulose (hpc) on the release rate of drug was investigated. crystals were generated by the anti-solvent approach using the hpc solution in water as the anti-solvent. the samples were subjected to various physicochemical evaluations such as crystal size, scanning electron microscopy, fourier transform i...
Historically, recombinant membrane protein production has been a major challenge meaning that many fewer membrane protein structures have been published than those of soluble proteins. However, there has been a recent, almost exponential increase in the number of membrane protein structures being deposited in the Protein Data Bank. This suggests that empirical methods are now available that can...
Obtaining well-ordered crystals is a major hurdle to X-ray structure determination of membrane proteins. To facilitate crystal optimization, we investigated the detergent stability of 24 eukaryotic and prokaryotic membrane proteins, predominantly transporters, using a fluorescent-based unfolding assay. We have benchmarked the stability required for crystallization in small micelle detergents, a...
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