The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila by isolating nascent RNA from adult fly heads and subjecting samples to high throughput sequencing. There are a large number of edited sites within nascent exons. Nascent RNA from an ADAR-null strain was ...

The highly conserved ADAR enzymes, found in all multicellular metazoans, catalyze the editing of mRNA transcripts by the deamination of adenosines to inosines. This type of editing has two general outcomes: site specific editing, which frequently leads to recoding, and clustered editing, which is usually found in transcribed genomic repeats. Here, for the first time, we looked for both editing ...

RNA editing in higher plant mitochondria modifies mRNA sequences by means of C-to-U conversions at highly specific sites. To determine the cis elements involved in recognition of an editing site in plant mitochondria, deletion and site-directed mutation constructs containing the cognate cox II mitochondrial gene were introduced into purified mitochondria by electroporation. The RNA editing stat...

The ability to collaboratively edit work artefacts is important in many kinds of editing tools, including Computer-Aided Design (CAD) tools, Computer-Aided Software Engineering (CASE) tools, drawing packages, and document editors. However, most existing such tools either do not support collaborative editing or provide limited collaborative editing facilities. We describe our recent work in addi...

background and aim: today, bilingualism is a developing phenomenon which half of the world population is bilingual. auditory system is the main route to language learning, so it is expected that bilingualism has an effect on functions of the auditory system. auditory memory is one of the auditory processes which is a cornerstone of linguistic skills and learning process growth, so that, it has ...

bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

This paper presents a novel version control system for point clouds, which allows the complete editing history of dataset to be stored. For each intermediate version, this stores only information that changes with respect previous one, is compressed using new strategy based on several algorithms. It undo/redo functionality in memory, serves optimize operation system. can also manage produced fr...

objectives: the prospective and retrospective memory questionnaire (prmq) developed by smith (2000) and consists of a series of questions about memory weakness that can be encountered anyone in everyday life. the self-reported questionnaire has 16 items that assessing of prospective and retrospective memory problems in everyday life and the aim of the present research was to examine the investi...