N-Myristoyltransferase (NMT) transfers myristate to an amino-terminal glycine of many eukaryotic proteins. In yeast, worms, and flies, this enzyme is essential for viability of the organism. Humans and mice possess two distinct but structurally similar enzymes, NMT1 and NMT2. These two enzymes have similar peptide specificities, but no one has examined the functional importance of the enzymes i...

If, in some cataclysm, all of scientific knowledge were to be destroyed, and only one sentence passed on to the next generations of creatures, what statement would contain the most information in the fewest words? I believe it is the atomic hypothesis (or the atomic fact, or whatever you wish to call it) that all things are made of atoms—little particles that move around in perpetual motion, at...

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious and hemorrhagic disease recently described in China and western Japan. A 71-year-old healthy Japanese woman noticed a tick biting her after harvesting in an orchard and removed it herself. She developed diarrhea, anorexia, and chills eight days later. Because these symptoms continued, she visited a primary care physici...

BACKGROUND Ciprofloxacin is a commonly used fluoroquinolone antibiotic. It is occasionally associated with benign elevations in liver enzymes. Few reports in the literature correlate ciprofloxacin with significant liver injury. We present a fatal case of ciprofloxacin-induced liver failure. CASE REPORT  A 74-year-old female was successfully treated with ciprofloxacin for a urinary tract infecti...

this paper presents a model of a catchment area in northwest of iran. the researchers have studied ajichai basin which is located in the east part of orumiyeh lake, located at the longitude of 47 52’ e to 45 32’ e and the latitude of 37 26’ n to 38 30’ n. the researchers have chosen the data from tabriz upper air station which is the only one in the area. the research data are seven instability...

In a developing country with varying degree of public hygiene and sanitation, prevalent infectious diseases such as hepatitis A (HAV) could add to the burden infection during coronavirus disease 2019 (COVID-19) pandemic complicate its gastrointestinal hepatic manifestation. Here we present case COVID-19 acute virus co-infection in young female fever, joint pain, non-productive cough, loss smell...

Many genetic studies recently have focused on HLA, VDR, NRAMP1, MBL, TNF-a, and their relationships with susceptibility to diseases such as pulmonary tuberculosis. Some studies showed predisposing and protective roles for VDR polymorphisms in pulmonary tuberculosis. Through a case-control study, blood samples were taken from tuberculosis case (n= 164) and control (n= 50) groups. DNA was extract...

The serum proteinograms of 10 female Holstein calves fed milk either through conventional (COV) or step-down (STP) milk feeding methods at different ages were evaluated. Calves fed using the COV method were fed colostrum during the first 24 hours that they stayed with their respective mothers and received transition milk for another 2 days and later, and then milk at four liters/day for 59 days...