نتایج جستجو برای: merrf
تعداد نتایج: 762 فیلتر نتایج به سال:
We characterized a new signaling pathway leading to the activation of cAMP-responsive element-binding protein (CREB) in several cell lines affected by mitochondrial dysfunction. In vitro kinase assays, inhibitors of several kinase pathways and overexpression of a dominant-negative mutant for calcium/calmodulin kinase IV (CaMKIV), which blocks the activation of CREB, showed that CaMKIV is activa...
With interestwe read the article by Zanolini et al. about a 21 yomale with exercise-intolerance since age 7 y, recurrent vomiting since age 17 y, muscle wasting, decreased tendon reflexes, high-arched palate and mal-occlusion detected at age 20 y, exercise-induced supraventricular tachycardia, and lactic acidosis due to a ND2 mutation [1]. The patient profited from coenzyme-Q [1]. We have the f...
BACKGROUND Mitochondrial myopathies (MM) are a heterogeneous group of inherited conditions resulting from a primary defect in the mitochondrial respiratory chain with consecutively impaired cellular energy metabolism. Small sized studies using mainly electrocardiography (ECG) and echocardiography have revealed cardiac abnormalities ranging from conduction abnormalities and arrhythmias to hypert...
The functional properties of cutaneous afferent fibers were investigated 1-15 mo after nerve lesions, which allowed regeneration into denervated skin. After crushing or transection and resuturing the rat sural nerve, ongoing activity and responses to cold, heat, and mechanical stimuli presented to the denervated skin or to the nerve distal to the lesion were examined in 273 A-fibers and 211 C-f...
BACKGROUND The spared nerve injury (SNI) model of neuropathic pain produces robust and reproducible behavioral mechanical hypersensitivity. Although this rodent model of neuropathic pain has been well established and widely used, peripheral mechanisms underlying this phenotype remain incompletely understood. Here we investigated the role of cutaneous sensory fibers in the maintenance of mechani...
Selective arterial embolization for uncontrollable urethral hemorrhage in a patient with a left ventricular assist device Yujiro Hayashi , Atsunari Kawashima a, , Kazutoshi Fujita , Taigo Kato , Toyofumi Abe , Takeshi Ujike , Akira Nagahara , Shinichiro Fukuhara , Motohide Uemura , Hiroshi Kiuchi , Ryoichi Imamura , Tetsuya Saito , Koichi Toda , Yoshiki Sawa , Kentaro Kishimoto c, , Keigo Osuga...
This study was carried out to determine the effect of 2-aminoethoxydiphenyl borate (2-APB), a common activator of transient receptor potential vanilloid (TRPV) type 1, 2, and 3 channels, on cardiorespiratory reflexes, pulmonary C fiber afferents, and isolated pulmonary capsaicin-sensitive neurons. In anesthetized, spontaneously breathing rats, intravenous bolus injection of 2-APB elicited the p...
Natural coir fibers, subjectd to thermal treatments in the range of 0oC to 200oC and alkali treatment with 5% to 30% concentration w/w, have been used in the present investigation to determine the interlayer variability of the cellulose planes (020), (110) and (110). Among the equatorial reflections (110), (110) and (020), the extent of variability is found to be more with the proportion of suc...
Photodarkening behavior in Yb-doped aluminosilicate fibers at elevated temperatures is reported. The fiber was core-pumped at 977 nm and the transmitted powers were monitored at 633 (probe) and 977 nm (pump) simultaneously with ~47% of population inversion of Yb ions. A saturated photodarkening loss was found, which is inversely proportional to temperature and, at ~573 K, the loss was negligibl...
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