نتایج جستجو برای: mesenchymal tumor
تعداد نتایج: 479087 فیلتر نتایج به سال:
BACKGROUNDS Angiomyofibroblastoma (AMFB) is a rare histopathologic finding of the female lower genital tract. This tumor belongs to the group of mesenchymal tumors. Mesenchymal neoplasms of the modified genital skin and mucosa are uncommon. The majority of these lesions are seen in females and, collectively, they form a family of vulvovaginal soft tissue tumors. This family includes fibroepithe...
NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. In murine models, genetic ablation of the NOTCH pathway accelerated bladder tumorigenesis and promoted the formation of squamous cell carcinomas, with areas of mesenchymal feature...
stromal tumor that develops from gastro-intestinal (GI) mesenchymal cells from the esophagus to the rectum. Before 1990, most investigators thought these mesencgymal cell tumor to be the neoplasm from smooth muscle of gastrointestinal tract, and considered that these tumors were one kind of leiomyoma, leomyosarcoma or leiomyoblastoma. With the advent of immuno-chemical staining and ultra-struct...
Tumor metastasis is the main cause of death in patients with solid tumors. The epithelial-mesenchymal transition (EMT) process, in which epithelial cells are converted into mesenchymal cells, is frequently activated during cancer invasion and metastasis. MicroRNAs (miRNAs) are small, non-coding RNAs that provide widespread expressional control by repressing mRNA translation and inducing mRNA de...
Adrenal myelolipoma is a rare benign neoplasm of mesenchymal origin composed mature fatty tissue and bone marrow elements. It non-functioning tumor, usually asymptomatic commonly detected incidentally during evaluation for unrelated symptoms; hence, it referred to as an “incidentaloma”. Large myelolipomas can cause mass effects vague abdominal pain, spontaneous tumor rupture with massive hemorr...
To determine the incidence of genetic heterogeneity in primary prostate cancer, we have microdissected 125 tumor and mesenchymal foci from 18 patient biopsies and analyzed the DNA for loss of heterozygosity using PCR microsatellite markers. In 100% of patients with genetic lesions on chromosome 8p, there was evidence for intratumoral genetic heterogeneity. There was also a low but significant i...
The metastatic spread of tumor epithelial cells accounts for over 90% of cancer-specific mortality; however, the molecular mechanisms that govern tumor spread and distant recolonization remain unclear. In this issue of JCI, Rokavec and colleagues shine light on this murky aspect of tumor biology by focusing through the lens of microenvironmental contributions, namely inflammation, as driving si...
Introduction: Mesenchymal stem cells (MSCs) are present in most tissues of the body. These cells are involved in various biological processes, such as maintaining tissue homeostasis and wound healing. Recent studies have shown that tumor associated MSCs (TA-MSCs) are also present in tumor microenvironment (TME) of most solid tumors. MSCs have a strong tendency to migration toward tumor tissues....
BACKGROUND Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the...
Received October 2009 Accepted November 2009 INTRODUCTION A gastrointestinal stromal tumor (GIST) is primarily located in the gastrointestinal tract. It is classified as a mesenchymal tumor that shows a CD117 (c-KIT)-positive mesenchymal spindle or epithelioid neoplasm. Tumors outside the gastrointestinal tract that were histologically similar to GISTs and showed immunopositivity for CD117 were...
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